| Growth regulation by oncogenes--new insights from model organisms. | |
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MedLine Citation:
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PMID: 11163146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A great deal of work has focused on how oncogenes regulate the cell cycle during normal development and in cancer, yet their roles in regulating cell growth have been largely unexplored. Recent work in several model organisms has demonstrated that homologs of several oncogenes regulate cell growth and has suggested that some of the effects of oncogenes on the cell cycle may be a result of growth promotion. These studies have also suggested how growth and cell-cycle progression may be coupled. |
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Authors:
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D A Prober; B A Edgar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 11 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 19-26 Citation Subset: IM |
Affiliation:
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Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. dprober@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division Cell Transformation, Neoplastic / genetics* Cyclin D Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases / genetics, metabolism Cyclins / genetics, metabolism Gene Expression Regulation, Neoplastic* Genes, cdc Genes, myc Genes, ras Humans Mutation Proto-Oncogene Proteins* Proto-Oncogenes* Somatomedins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cyclin D; 0/Cyclins; 0/Proto-Oncogene Proteins; 0/Somatomedins; EC 2.7.1.37/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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