| Growth and pulmonary outcomes during the first 2 y of life of breastfed and formula-fed infants diagnosed with cystic fibrosis through the Wisconsin Routine Newborn Screening Program. | |
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MedLine Citation:
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PMID: 21430114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The optimal feeding (breast milk, formula, or a combination) for infants with cystic fibrosis (CF) is unknown. Recommendations from the CF Foundation are based on limited data. OBJECTIVE: We compared growth and pulmonary outcomes between breastfed and formula-fed infants through the age of 2 y. DESIGN: A total of 103 CF infants born in 1994-2006 and diagnosed through newborn screening in Wisconsin were studied. Breastfed infants were classified by the duration of exclusive breastfeeding (ExBF). Exclusive formula-feeding (ExFM) was classified by the formula's caloric density (ie, standard [0.67 kcal/mL (20 kcal/oz) (ExFM20)] throughout infancy or high density [≥0.74 kcal/mL (22 kcal/oz) (ExFM22+)] for some duration of infancy). RESULTS: Fifty-three infants (51% of infants) were breastfed and 50 infants (49% of infants) were ExFM. In breastfed infants, the duration of ExBF was <1 mo (53% of infants), 1-1.9 mo (21% of infants), 2-3 mo (17% of infants), and 4-9 mo (9% of infants). In ExFM infants, 23 infants (46%) received a formula with a high caloric density; approximately half (n = 13) of the ExFM infants received the formula by 6 mo of age. Proportionately more infants with pancreatic sufficiency (n = 9) were ExBF ≥1 mo (44% of infants), and none of the infants were ExFM22+, compared with infants with meconium ileus (n = 24; 13% of infants were ExBF ≥1 mo, and 38% of infants were ExFM22+) or pancreatic insufficiency (n = 70; 25% of infants were ExBF ≥1 mo, and 20% of infants were ExFM22+) (P = 0.02). In infants with pancreatic insufficiency, weight z scores declined from birth to 6 mo (P < 0.0001) in infants who were ExBF ≥2 mo, and the number of Pseudomonas aeruginosa infections through the age of 2 y was fewer in breastfed than in ExFM infants (P = 0.003) but did not differ by the duration of ExBF. CONCLUSION: For infants with CF, ExBF <2 mo does not compromise growth and is associated with a respiratory benefit. |
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Authors:
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Sarah A Jadin; Grace S Wu; Zhumin Zhang; Suzanne M Shoff; Benjamin M Tippets; Philip M Farrell; Tami Miller; Michael J Rock; Hara Levy; HuiChuan J Lai |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-23 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 93 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-21 Completed Date: 2011-07-15 Revised Date: 2013-03-13 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1038-47 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison, WI 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Feeding* Child Development* Child, Preschool Cystic Fibrosis / diet therapy*, immunology, pathology, physiopathology* Exocrine Pancreatic Insufficiency / epidemiology, etiology Female Humans Infant Infant Formula* Infant, Newborn Longitudinal Studies Lung / immunology, microbiology, pathology* Male Mass Screening Medical Records Pneumonia / microbiology* Pseudomonas Infections / epidemiology, microbiology, prevention & control Pseudomonas aeruginosa / isolation & purification Severity of Illness Index Time Factors Wisconsin / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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DK34108/DK/NIDDK NIH HHS; R01 DK072126/DK/NIDDK NIH HHS; R01DK72126/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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