Document Detail


Growth-promoting properties of the internal milieu of pregnant and lactating rats.
MedLine Citation:
PMID:  2301573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The growth-promoting properties of the internal milieu of pregnant and lactating rats were investigated using transplanted whole rat embryos or fetal paws. When placed under the kidney capsule of intact nonpregnant hosts and incubated for 12 days, such transplants grow rapidly, and tissues differentiate normally. Thus they provide an accurate means of assessing the growth-promoting properties of the internal environment of host animals in different physiological states. Transplant growth during days 0-11 of pregnancy was similar to that observed in age-matched virgin control hosts during an equivalent 12-day period. However, growth of transplants was decreased by 40% in hosts during days 10-22 of pregnancy and by approximately 30% in hosts during days 1-13 or days 11-23 of lactation. Increase in tail length, which was used as an index of maternal skeletal growth, was reduced by 50% during the second half of pregnancy and the early and late periods of lactation compared with age-matched virgin females. No such inhibition was recorded during the first half of pregnancy. Compared with virgins, serum insulin-like growth factor I (IGF-I) levels were reduced by approximately 20% on days 6 and 10 of pregnancy, and by 63-66% during the second half of gestation. Serum IGF-I levels rose during lactation to reach prepregnancy levels by day 12, but a second decline occurred by day 18 postpartum.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M Chiang; S M Russell; C S Nicoll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-01     Completed Date:  1990-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E98-102     Citation Subset:  IM    
Affiliation:
Department of Integrative Biology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryo Transfer
Embryo, Mammalian / physiology*
Female
Fetus
Forelimb / embryology,  transplantation*
Growth Hormone / pharmacology
Insulin-Like Growth Factor I / metabolism
Lactation / physiology*
Pregnancy
Pregnancy, Animal / physiology*
Rats
Reference Values
Grant Support
ID/Acronym/Agency:
HD-14661/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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