Document Detail

Growth and patterning in the limb: signaling gradients make the decision.
MedLine Citation:
PMID:  19141858     Owner:  NLM     Status:  MEDLINE    
The vertebrate limb bud provides a unique system to investigate the coordinated regulation of growth and patterning, two key processes that govern the formation of a complex multicellular organism from a fertilized egg. Two studies have advanced our understanding of limb development by elucidating that signaling gradients from the limb ectoderm, including the apical ectoderm ridge (AER), act in concert to establish a basic pattern of tissue layers by coordinating cell proliferation and cell fate determination. These studies reveal that cell proliferation and fate determination in development can be two faces of the same coin in that they are regulated by the same signaling pathways. Alterations in the duration and range of the signaling gradients may underlie many of the morphological differences in the evolution of vertebrate limbs.
Yingzi Yang
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-01-13
Journal Detail:
Title:  Science signaling     Volume:  2     ISSN:  1937-9145     ISO Abbreviation:  -     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-02-13     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe3     Citation Subset:  IM    
Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA.
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MeSH Terms
Body Patterning / physiology*
Cell Division
Cell Lineage
Ectoderm / physiology
Embryonic Development / physiology
Extremities / embryology*
Fibroblast Growth Factors / physiology
Intercellular Signaling Peptides and Proteins / physiology
Mesoderm / physiology
Osmolar Concentration
Signal Transduction / physiology*
Vertebrates / embryology*
Wnt Proteins / physiology
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Wnt Proteins; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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