| Growth and patterning in the limb: signaling gradients make the decision. | |
MedLine Citation:
|
PMID: 19141858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The vertebrate limb bud provides a unique system to investigate the coordinated regulation of growth and patterning, two key processes that govern the formation of a complex multicellular organism from a fertilized egg. Two studies have advanced our understanding of limb development by elucidating that signaling gradients from the limb ectoderm, including the apical ectoderm ridge (AER), act in concert to establish a basic pattern of tissue layers by coordinating cell proliferation and cell fate determination. These studies reveal that cell proliferation and fate determination in development can be two faces of the same coin in that they are regulated by the same signaling pathways. Alterations in the duration and range of the signaling gradients may underlie many of the morphological differences in the evolution of vertebrate limbs. |
Authors:
|
Yingzi Yang |
Related Documents
:
|
14711878 - Expression dynamics of wox genes mark cell fate decisions during early embryonic patter... 16113648 - Numb and alpha-adaptin regulate sanpodo endocytosis to specify cell fate in drosophila ... 12681948 - Regulation of b cell development by notch/rbp-j signaling. 10490098 - Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the... 10712518 - Periodic expression of the cyclin-dependent kinase inhibitor p57(kip2) in trophoblast g... 18197168 - Inter-kingdom signalling: communication between bacteria and their hosts. |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-01-13 |
Journal Detail:
|
Title: Science signaling Volume: 2 ISSN: 1937-9145 ISO Abbreviation: - Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-14 Completed Date: 2009-02-13 Revised Date: 2009-03-03 |
Medline Journal Info:
|
Nlm Unique ID: 101465400 Medline TA: Sci Signal Country: United States |
Other Details:
|
Languages: eng Pagination: pe3 Citation Subset: IM |
Affiliation:
|
Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA. yingzi@mail.nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Patterning / physiology* Cell Division Cell Lineage Ectoderm / physiology Embryonic Development / physiology Extremities / embryology* Fibroblast Growth Factors / physiology Intercellular Signaling Peptides and Proteins / physiology Mesoderm / physiology Morphogenesis Osmolar Concentration Signal Transduction / physiology* Vertebrates / embryology* Wnt Proteins / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Intercellular Signaling Peptides and Proteins; 0/Wnt Proteins; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Science signaling podcast: 13 january 2009.
Next Document: Activin-A attenuates several human natural killer cell functions.