Document Detail


Growth of only highly tumorigenic cell lines is inhibited by EAP, a human placental fraction.
MedLine Citation:
PMID:  8330307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously shown that a fraction from a human placental extract, EAP, inhibited growth in soft agar of a human lung squamous adenocarcinoma cell line, A-2182, and of Ha-ras oncogene-transfected murine BALB/c 3T3 cells. We report here the activities of this extract on several cell lines which have different degrees of transformed phenotype. Human esophagus and colorectal cell lines were derived from tumors at different stages of neoplasic progression, and murine BALB/c 3T3 cells were transfected with various oncogenes. In all three models, growth of the most highly tumorigenic cells was inhibited by the presence of EAP in soft agar medium, while growth of non- and low tumorigenic counterparts was not affected or was stimulated by the placental extract. In addition, EAP did not significantly affect the doubling time of anchorage-dependent cell growth, suggesting that EAP specifically suppresses tumorigenic characteristics of cells such as their ability to grow in soft agar medium. These effects appear to be in contrast to those of transforming growth factor beta, which exerts its most profound effect on less tumorigenic cells.
Authors:
J L Klein; C Chiodino; H Yamasaki
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  70     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-17     Completed Date:  1993-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-9     Citation Subset:  IM    
Affiliation:
Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells / pathology
Animals
Cell Adhesion
Cell Division / drug effects
Colorectal Neoplasms / pathology*
Culture Media
Esophageal Neoplasms / pathology*
Humans
Mice
Oncogenes
Placental Extracts / pharmacology*
Transfection
Tumor Cells, Cultured
Tumor Stem Cell Assay
Grant Support
ID/Acronym/Agency:
R01 CA40534/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media; 0/Placental Extracts

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