| Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 16737874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness. STUDY DESIGN: Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation. RESULTS: Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p > or = .06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ. CONCLUSIONS: Metformin during lactation appears to be safe and effective in the first 6 months of infancy. |
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Authors:
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Charles J Glueck; Marzieh Salehi; Luann Sieve; Ping Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 148 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-06-01 Completed Date: 2006-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 628-632 Citation Subset: AIM; IM |
Affiliation:
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Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bottle Feeding Breast Feeding* Child Development Female Follow-Up Studies Humans Hypoglycemic Agents / therapeutic use* Infant Formula Infant, Newborn / growth & development* Male Metformin / therapeutic use* Polycystic Ovary Syndrome / drug therapy* Pregnancy Pregnancy Complications / drug therapy* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2006 May;148(5):573-4
[PMID:
16737862
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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