Document Detail

Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome.
MedLine Citation:
PMID:  16737874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness. STUDY DESIGN: Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation. RESULTS: Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p > or = .06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ. CONCLUSIONS: Metformin during lactation appears to be safe and effective in the first 6 months of infancy.
Charles J Glueck; Marzieh Salehi; Luann Sieve; Ping Wang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  148     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-01     Completed Date:  2006-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  628-632     Citation Subset:  AIM; IM    
Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA.
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MeSH Terms
Bottle Feeding
Breast Feeding*
Child Development
Follow-Up Studies
Hypoglycemic Agents / therapeutic use*
Infant Formula
Infant, Newborn / growth & development*
Metformin / therapeutic use*
Polycystic Ovary Syndrome / drug therapy*
Pregnancy Complications / drug therapy*
Prospective Studies
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin
Comment In:
J Pediatr. 2006 May;148(5):573-4   [PMID:  16737862 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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