| Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. | |
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MedLine Citation:
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PMID: 6093254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Purified growth inhibitor from BSC-1 cells and type beta transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type beta transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions. |
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Authors:
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R F Tucker; G D Shipley; H L Moses; R W Holley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 226 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1984-12-05 Completed Date: 1984-12-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 705-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / metabolism Cercopithecus aethiops DNA / biosynthesis Growth Inhibitors / isolation & purification, metabolism*, pharmacology Peptides / metabolism*, pharmacology Receptors, Cell Surface / metabolism Transforming Growth Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA 09441/CA/NCI NIH HHS; CA 16816/CA/NCI NIH HHS; CA 27217/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Peptides; 0/Receptors, Cell Surface; 76057-06-2/Transforming Growth Factors; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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