Document Detail


Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.
MedLine Citation:
PMID:  6093254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Purified growth inhibitor from BSC-1 cells and type beta transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type beta transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions.
Authors:
R F Tucker; G D Shipley; H L Moses; R W Holley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  226     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  705-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Cercopithecus aethiops
DNA / biosynthesis
Growth Inhibitors / isolation & purification,  metabolism*,  pharmacology
Peptides / metabolism*,  pharmacology
Receptors, Cell Surface / metabolism
Transforming Growth Factors
Grant Support
ID/Acronym/Agency:
CA 09441/CA/NCI NIH HHS; CA 16816/CA/NCI NIH HHS; CA 27217/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Growth Inhibitors; 0/Peptides; 0/Receptors, Cell Surface; 76057-06-2/Transforming Growth Factors; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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