Document Detail

Growth inhibition of transformed cells correlates with their junctional communication with normal cells.
MedLine Citation:
PMID:  2416473     Owner:  NLM     Status:  MEDLINE    
The growth of various chemically and virally transformed cell types in culture is inhibited when they are in contact with normal cell types. We show that this growth inhibition is contingent on the presence of junctional communication between the normal and transformed cells (heterologous communication), as probed with a 443 dalton microinjected fluorescent tracer. In cell combinations where heterologous communication is weak or absent there is no detectable growth inhibition; the inhibition appears when communication is induced by cyclic AMP-dependent phosphorylation, and only then. In cell combinations where heterologous communication is spontaneously strong, the growth inhibition is present, but it is abolished when the communication is blocked by retinol or retinoic acid. The cell-to-cell membrane channels of gap junctions are the likely conduits of the signals for this growth control.
P P Mehta; J S Bertram; W R Loewenstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  44     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-19     Completed Date:  1986-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-96     Citation Subset:  IM    
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MeSH Terms
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / pharmacology
Cell Communication*
Cell Transformation, Neoplastic / chemically induced,  drug effects,  physiopathology*
Contact Inhibition*
Cyclic AMP / physiology
Forskolin / pharmacology
Intercellular Junctions / physiology*
Ion Channels / physiology
Tretinoin / pharmacology
Vitamin A / pharmacology
Xanthines / pharmacology
Grant Support
Reg. No./Substance:
0/Ion Channels; 0/Xanthines; 11103-57-4/Vitamin A; 28109-92-4/methylxanthine; 29925-17-5/4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 302-79-4/Tretinoin; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin

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