Document Detail

Growth inhibition mode of action of selected benzoic acid derivatives against the yeast Pichia anomala.
MedLine Citation:
PMID:  19435228     Owner:  NLM     Status:  MEDLINE    
Three benzoic acid derivatives (zinc p-iodobenzoate, zinc p-hydroxybenzoate, and zinc p-aminobenzoate) were synthesized and tested chemically and microbiologically in order to explain their mode of action against the yeast Pichia anomala. The yeast strains were cultivated in batch culture of chemically defined minimal medium (control) and with the addition of the studied compound at concentrations of 0.103 to 0.166% (wt/vol). The growth of microorganisms, H+ concentration, and the concentrations of both dissociated and undissociated forms of the appropriate weak acid in the medium were monitored at 1-h intervals during 24 h of incubation. The inhibitory effect of each compound on the growth of microorganisms was calculated based on measurement of optical density at 600 nm turbidity. The K parameter, defined as the ratio of the concentration of undissociated weak acid to the number of microorganisms in the medium, was determined. The K value is related to the degree of growth inhibition and provides new insight into the mode of action of weak organic acids against the studied yeasts. The buffering capacity of the chemicals studied was also found to be an inhibition parameter associated with microbial growth. Greater buffer capacity of a given compound reduced changes in the pH value of the medium, resulting in changes to antimicrobial effectiveness.
P Koczoń
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food protection     Volume:  72     ISSN:  0362-028X     ISO Abbreviation:  J. Food Prot.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703944     Medline TA:  J Food Prot     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-800     Citation Subset:  IM    
Warsaw University of Life Sciences, Faculty of Food Sciences, Food Chemistry Department, ul. Nowoursynowska 159 C, 02-787 Warsaw, Poland.
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MeSH Terms
Benzoates / pharmacology*
Dose-Response Relationship, Drug
Food Microbiology
Food Preservation
Food Preservatives / pharmacology*
Pichia / drug effects*
Time Factors
Yeasts / drug effects
Reg. No./Substance:
0/Benzoates; 0/Food Preservatives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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