| Growth inhibition mode of action of selected benzoic acid derivatives against the yeast Pichia anomala. | |
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MedLine Citation:
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PMID: 19435228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three benzoic acid derivatives (zinc p-iodobenzoate, zinc p-hydroxybenzoate, and zinc p-aminobenzoate) were synthesized and tested chemically and microbiologically in order to explain their mode of action against the yeast Pichia anomala. The yeast strains were cultivated in batch culture of chemically defined minimal medium (control) and with the addition of the studied compound at concentrations of 0.103 to 0.166% (wt/vol). The growth of microorganisms, H+ concentration, and the concentrations of both dissociated and undissociated forms of the appropriate weak acid in the medium were monitored at 1-h intervals during 24 h of incubation. The inhibitory effect of each compound on the growth of microorganisms was calculated based on measurement of optical density at 600 nm turbidity. The K parameter, defined as the ratio of the concentration of undissociated weak acid to the number of microorganisms in the medium, was determined. The K value is related to the degree of growth inhibition and provides new insight into the mode of action of weak organic acids against the studied yeasts. The buffering capacity of the chemicals studied was also found to be an inhibition parameter associated with microbial growth. Greater buffer capacity of a given compound reduced changes in the pH value of the medium, resulting in changes to antimicrobial effectiveness. |
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Authors:
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P Koczoń |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food protection Volume: 72 ISSN: 0362-028X ISO Abbreviation: J. Food Prot. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-13 Completed Date: 2009-07-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703944 Medline TA: J Food Prot Country: United States |
Other Details:
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Languages: eng Pagination: 791-800 Citation Subset: IM |
Affiliation:
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Warsaw University of Life Sciences, Faculty of Food Sciences, Food Chemistry Department, ul. Nowoursynowska 159 C, 02-787 Warsaw, Poland. piotr_koczon@sggw.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzoates
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pharmacology* Dose-Response Relationship, Drug Food Microbiology Food Preservation Food Preservatives / pharmacology* Pichia / drug effects* Time Factors Yeasts / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Food Preservatives |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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