Document Detail


Growth inhibition of leukaemic cells carrying the t(3;21) by the AML1/EVI-1-specific antisense oligonucleotide.
MedLine Citation:
PMID:  7647015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The t(3;21)(q26;q22) translocation is thought to play an important role in the acute phase transformation of CML. The formation of the AML1/EVI-1 fusion gene by the translocation leads to expression of the AML1/EVI-1 fusion protein. Here we demonstrate that the AML1/EVI-1-specific antisense oligonucleotide markedly decreases the [3H]thymidine incorporation and growth of leukaemic cells carrying the t(3;21) and the t(9;22), but not those of K562 cells. These results indicate that the AML1/EVI-1 fusion protein could contribute to proliferation of the t(3;21)-carrying leukaemic cells after entering the blastic crisis phase of CML.
Authors:
K Mitani; S Ogawa; T Tanaka; M Kurokawa; Y Yazaki; H Hirai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  90     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  711-4     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Cell Division
Chromosomes, Human, Pair 21*
Chromosomes, Human, Pair 3*
Humans
Leukemia, Myeloid, Acute / genetics*,  pathology
Molecular Sequence Data
Oligonucleotides, Antisense / genetics*
Oncogene Proteins, Fusion
Translocation, Genetic*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Oligonucleotides, Antisense; 0/Oncogene Proteins, Fusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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