Document Detail

Growth inhibition of head and neck carcinomas by D-allose.
MedLine Citation:
PMID:  19340872     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An inhibitory effect of D-allose, a rare sugar, on several cancer cell lines has been reported. This study aimed to investigate the growth inhibition of head and neck squamous cell carcinoma cells by D-allose. METHODS: We treated 3 head and neck carcinoma cell lines with D-allose, D-fructose, D-psicose, and D-glucose. Cell growth assays as well as analyses of messenger RNA (mRNA) expression, cell cycle, apoptosis, and uptake of 14C-glucose were performed. RESULTS: D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2. We observed that D-allose tended to interfere with the intracellular uptake of D-glucose and induced apoptosis. CONCLUSION: Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients.
Tomoo Mitani; Hiroshi Hoshikawa; Terushige Mori; Tomohiro Hosokawa; Ikuko Tsukamoto; Fuminori Yamaguchi; Kazuyo Kamitori; Masaaki Tokuda; Nozomu Mori
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  31     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1049-55     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley Periodicals, Inc.
Department of Otorhinolaryngology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
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MeSH Terms
Apoptosis / drug effects*
Carcinoma, Squamous Cell / drug therapy,  pathology
Cell Cycle / drug effects,  physiology
Cell Growth Processes / drug effects
Cell Line, Tumor / drug effects
Cell Proliferation / drug effects*
Dose-Response Relationship, Drug
Glucose / metabolism,  pharmacology*
Head and Neck Neoplasms / drug therapy,  pathology
In Situ Nick-End Labeling
Mouth Neoplasms / drug therapy,  pathology
RNA, Messenger / analysis
Sensitivity and Specificity
Reg. No./Substance:
0/RNA, Messenger; 50-99-7/Glucose; 6038-51-3/allose

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