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Growth in early life and the development of obesity by age 9 years: are there critical periods and a role for an early life stressor?
MedLine Citation:
PMID:  23318715     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:Rapid growth, possibly occurring in critical periods in early life, may be important for the development of obesity. It is unknown whether this is influenced by postnatal exposures such as age-relevant sources of stress. Frequent house moves may be one such stressor. We aimed to examine if there is a period of growth in early life critical for the development of child obesity by age 9 years and assess the role of house moves in modifying any relationships between early life growth and obesity at age 9 years.Design:Prospective Australian birth cohort study.Subjects:In all, 392 children with serial body size measurements from birth to age 9 years.Methods:Standardized body mass index (z-BMI) was available for six time points (spanning birth to 3½ years), and the total number of house moves between birth and 3½ years. The outcomes considered were z-BMI and % body fat (%BF) at age 9 years. Linear regression models were used to estimate the effects of serial measurements of z-BMI and number of house moves on the outcomes.Results:Life-course plots showed that z-BMI at 3½ years was a statistically significant predictor of z-BMI at 9 years (β=0.80; standard error (s.e.), 0.04), whereas z-BMI at 9 months (β=-1.13; s.e., 0.40) and 3½ years (β=4.82; s.e., 0.42) were significant predictors of %BF at age 9 years. There were statistically significant interactions between the number of house moves and change in z-BMI between 9 and 12 months, such that 3 house moves in early life amplified the detrimental effects of earlier rapid growth on both body size and composition at age 9 years.Conclusion:In the absence of evidence for a single critical period, efforts to prevent overweight and obesity are required throughout childhood. In addition, modifiable postnatal stressors may exacerbate effects of early growth on obesity in later childhood.International Journal of Obesity advance online publication, 15 January 2013; doi:10.1038/ijo.2012.219.
Authors:
L C Giles; M J Whitrow; A R Rumbold; C E Davies; B de Stavola; J B Pitcher; M J Davies; V M Moore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  -     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Discipline of Public Health, School of Population Health, The University of Adelaide, Adelaide, South Australia, Australia [2] Research Centre for the Early Origins of Health and Disease, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia.
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