Document Detail


Growth hormone treatment started in the first year of life in infants with chronic renal failure.
MedLine Citation:
PMID:  19159957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants with chronic renal failure (CRF) are at high risk of experiencing severe growth retardation. We report a study of 12 infants with CRF who have been treated with recombinant human growth hormone (rhGH) since the age of 0.5 +/- 0.3 years. A control group comprised 15 infants with less severe CRF who were being treated during the same period, but who did not receive rhGH. Despite the infants in the rhGH group had more severe renal failure, they grew at least as well as those in the control group and experienced catch-up growth that started earlier and was more sustained; they also gained more weight. Between the age of 0.5 and 2.5 years, the height standard deviation score (HtSDS) improved from -2.0 +/- 1.2 to -0.9 +/- 0.9 in the rhGH group (p < 0.005) and from -1.6 +/- 1.6 to -1.0 +/- 1.9 in the control group (p=non significant, n.s.). The average gain in HtSDS was +1.1 +/- 0.8 in the treated group and +0.6 +/- 1.4 in the control group (p = n.s.). During the same period, the weight SDS improved from -2.2 +/- 0.9 to -0.6 +/- 1.2 (p < 0.005) and from -1.9 +/- 1.2 to -1.3 +/- 1.2 (p=n.s.) in the treatment and control groups, respectively. Nutritional intake was similar in both groups, while parathyroid hormone levels tended to increase, although not significantly, after rhGH treatment (p=n.s.). The results of this pilot study suggest that very early treatment with rhGH in patients with early-onset CRF may improve growth.
Authors:
Francesca Mencarelli; Daniela Kiepe; Giovanna Leozappa; Gilda Stringini; Marco Cappa; Francesco Emma
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Publication Detail:
Type:  Journal Article     Date:  2009-01-22
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  24     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1039-46     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Urology, Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital and Research Institute (IRCCS), Piazza S Onofrio, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Body Size / drug effects*
Child, Preschool
Female
Follow-Up Studies
Growth Disorders / blood,  drug therapy*,  etiology
Human Growth Hormone / therapeutic use*
Humans
Infant
Kidney Failure, Chronic / blood,  complications,  drug therapy*
Male
Parathyroid Hormone / blood
Pilot Projects
Recombinant Proteins / therapeutic use*
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Recombinant Proteins; 12629-01-5/Human Growth Hormone
Comments/Corrections
Comment In:
Pediatr Nephrol. 2009 Jun;24(6):1093-6   [PMID:  19367419 ]
Pediatr Nephrol. 2009 Jun;24(6):1097-100   [PMID:  19373491 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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