Document Detail


Growth hormone therapy in heart failure: where are we now?
MedLine Citation:
PMID:  12671339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite improvement in survival with angiotensin-converting enzyme inhibitors and beta blockers, clinical events for patients with heart failure remain elevated. New therapies for heart failure are needed to improve functional capacity, quality of life, and prognosis. Growth hormone exerts direct and indirect effects on cardiac structure and function. Experimental models of heart failure and small studies have demonstrated significant improvements in cardiac function, hemodynamic parameters, functional capacity, and quality of life. Despite the lack of benefit demonstrated in small, short-term, randomized clinical trials, further studies are needed to assess the potential role of this adjuvant therapy in heart failure patients.
Authors:
Catherine Demers; Robert S McKelvie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  9     ISSN:  1527-5299     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-04-02     Completed Date:  2003-06-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
Copyright 2003 CHF, Inc.
Affiliation:
Hamilton Health Sciences (HHS), HHS-General Division, Hamilton, Ontario, L8L 2X2 Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clinical Trials as Topic
Growth Hormone / physiology*,  therapeutic use*
Heart Failure / drug therapy*,  physiopathology*
Hemodynamics / drug effects
Humans
Insulin-Like Growth Factor I / physiology,  therapeutic use
Myocardial Contraction / drug effects
Quality of Life
Ventricular Remodeling / drug effects
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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