Document Detail


Growth hormone therapy during neonatal hypoxia in rats: body composition, bone mineral density, and insulin-like growth factor-1 expression.
MedLine Citation:
PMID:  11887935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypoxia from birth results in a decrease in body weight gain, body size, and bone mineral density (BMD). The purpose of the present study was to determine whether short-term administration of growth hormone (GH) (rat GH; 100 microg/d) could attenuate some of these effects of neonatal hypoxia. Rat pups (with their lactating dams) were exposed to hypoxia (vs normoxic control) from birth. Hypoxia was continued until 14 d of age, with rat GH (vs vehicle control) administered daily. Hypoxia significantly inhibited body weight gain; GH therapy did not reverse this effect. GH therapy did reverse the inhibitory effect of hypoxia on tail length but not on body length. Hypoxia decreased BMD analyzed by dual X-ray absorptiometry (DXA); this effect was not reversed by GH therapy. Both GH therapy and hypoxia decreased the percentage of body fat analyzed by DXA, the effects of which were additive when combined. There were minimal effects of hypoxia and GH therapy on plasma insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, and hepatic IGF-1 mRNA expression. We conclude that some of the effects of hypoxia on body habitus are reversed by GH therapy, but that short-term GH therapy did not prevent a loss of BMD. GH therapy for more than 14 days may be necessary to appreciate fully its potential in the treatment of the sequelae of neonatal hypoxia.
Authors:
H Raff; E D Bruder; B Jankowski; M K Oaks; R J Colman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrine     Volume:  16     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-09-03     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Affiliation:
Endocrine Research Laboratories, St Luke's Medical Center, Milwaukee, WI 53215, USA. hraff@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Anoxia / drug therapy*,  metabolism,  pathology,  physiopathology
Body Composition / drug effects
Body Weight / drug effects
Bone Density / drug effects
Growth Hormone / therapeutic use*
Insulin-Like Growth Factor Binding Proteins / metabolism
Insulin-Like Growth Factor I / metabolism
Organ Size / drug effects
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK-54685/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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