Document Detail


Growth hormone signal transduction.
MedLine Citation:
PMID:  12099386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. GH-stimulated activation of signal transducers and activators of transcription (STATs), mitogen activated protein kinase (MAPK) and phosphatidylinositol 3' kinase (PI3K) cascades have been shown to regulate the transcription of GH-responsive genes. Cross-talk among these signaling cascades in regulating specific genes suggests that GH signaling to the nucleus involves a GH-regulated signaling network.
Authors:
Graciela Piwien-Pilipuk; Jeffrey S Huo; Jessica Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  15     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-12-17     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  771-86     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Michigan, Ann Arbor 48109-0622, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA-Binding Proteins / physiology
Gene Expression Regulation / physiology
Human Growth Hormone / physiology*
Humans
Insulin-Like Growth Factor I / physiology
Islets of Langerhans / physiology
Janus Kinase 2
Liver / metabolism
Milk Proteins*
Mitogen-Activated Protein Kinases / physiology
Phosphatidylinositol 3-Kinases / metabolism
Promoter Regions, Genetic / genetics
Protein-Tyrosine Kinases / physiology
Proto-Oncogene Proteins*
Receptor, Insulin / physiology
Receptors, Somatotropin / physiology
STAT5 Transcription Factor
Sex Characteristics
Signal Transduction / physiology*
Trans-Activators / physiology
Grant Support
ID/Acronym/Agency:
DK46072/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Milk Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Somatotropin; 0/STAT5 Transcription Factor; 0/Trans-Activators; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, Insulin; EC 2.7.10.2/JAK2 protein, human; EC 2.7.11.24/Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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