Document Detail

Growth hormone secretion in acid-base alterations at rest and during exercise.
MedLine Citation:
PMID:  4258     Owner:  NLM     Status:  MEDLINE    
1. Seven healthy males were studied during cycle ergometer exercise at 33%, 66% and 90% of VO2 max. on three occasions when NH4C1, NaHCO3 or CaCO3 (as a control substance) were administered in gelatin capsules double blind and in randomized order. Plasma growth hormone (HGH), lactic acid and hydrogen ion concentration ([H+]) were measured at frequent intervals. 2. Ammonium chloride produced highest blood [H+] and NaHCO3 the lowest. These differences were maintained during exercise and in recovery. Plasma lactic acid concentrations were similar at rest. At 66%, 90% VO2 max. and recovery lactic acid was highest with NaHCO3 and lowest with NH4C1. 3. Exercise stimulated HGH secretion in all studies and the elevation was proportional to the intensity of the exercise. NH4C1 caused a variable elevation of HGH at rest and 33% VO2 max. At 66% VO2 max., plasma HGH was significantly elevated to similar concentrations in all studies and, at 90% VO2 max., HGH was highest with NaHCO3. 4. An infusion of sodium L(+)-lactate producing plasma lactate concentrations of 3-5 mmol/l did not influence HGH secretion. 5. Exercise is a physiological stimulus to HGH secretion and the mechanism is independent of blood [H+] and lactate concentrations.
J R Sutton; N L Jones; C J Toews
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  50     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium*
Ammonium Chloride / pharmacology
Bicarbonates / pharmacology
Body Height
Body Weight
Calcium Carbonate / pharmacology
Exercise Test
Growth Hormone / blood*
Hydrogen-Ion Concentration
Lactates / blood
Physical Exertion*
Reg. No./Substance:
0/Bicarbonates; 0/Lactates; 12125-02-9/Ammonium Chloride; 471-34-1/Calcium Carbonate; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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