Document Detail


Growth hormone secretion in acid-base alterations at rest and during exercise.
MedLine Citation:
PMID:  4258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Seven healthy males were studied during cycle ergometer exercise at 33%, 66% and 90% of VO2 max. on three occasions when NH4C1, NaHCO3 or CaCO3 (as a control substance) were administered in gelatin capsules double blind and in randomized order. Plasma growth hormone (HGH), lactic acid and hydrogen ion concentration ([H+]) were measured at frequent intervals. 2. Ammonium chloride produced highest blood [H+] and NaHCO3 the lowest. These differences were maintained during exercise and in recovery. Plasma lactic acid concentrations were similar at rest. At 66%, 90% VO2 max. and recovery lactic acid was highest with NaHCO3 and lowest with NH4C1. 3. Exercise stimulated HGH secretion in all studies and the elevation was proportional to the intensity of the exercise. NH4C1 caused a variable elevation of HGH at rest and 33% VO2 max. At 66% VO2 max., plasma HGH was significantly elevated to similar concentrations in all studies and, at 90% VO2 max., HGH was highest with NaHCO3. 4. An infusion of sodium L(+)-lactate producing plasma lactate concentrations of 3-5 mmol/l did not influence HGH secretion. 5. Exercise is a physiological stimulus to HGH secretion and the mechanism is independent of blood [H+] and lactate concentrations.
Authors:
J R Sutton; N L Jones; C J Toews
Related Documents :
7957138 - Influence of lifting technique on perceptual and cardiovascular responses to submaximal...
16352678 - Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidat...
17694318 - Overall and peripheral ratings of perceived exertion during a graded exercise test to v...
1425628 - Transient and steady-state cardiopulmonary responses to combined rhythmic and isometric...
11924678 - Changes in mood status and neurotic levels during a 20-day bed rest.
15194038 - Comparison of plasma n-brain natriuretic peptide, peak oxygen consumption, and left ven...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  50     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium*
Adult
Ammonium Chloride / pharmacology
Bicarbonates / pharmacology
Blood
Body Height
Body Weight
Calcium Carbonate / pharmacology
Exercise Test
Growth Hormone / blood*
Humans
Hydrogen-Ion Concentration
Lactates / blood
Male
Physical Exertion*
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Lactates; 12125-02-9/Ammonium Chloride; 471-34-1/Calcium Carbonate; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Radiology in Mendelson's syndrome.
Next Document:  The intracellular pH of human leucocytes in response to acid-base changes in vitro.