| Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory. | |
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MedLine Citation:
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PMID: 22484009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the hormone ghrelin is best known for its stimulatory effect on appetite and regulation of growth hormone release, it is also reported to have beneficial effects on learning and memory formation in mice. Nevertheless, controversy exists about whether endogenous ghrelin acts on its receptors in extra-hypothalamic areas of the brain. The ghrelin receptor (GHS-R1a) is co-expressed in neurons that express dopamine receptor type-1 (DRD1a) and type-2 (DRD2), and we have shown that a subset of GHS-R1a, which are not occupied by the agonist (apo-GHSR1a), heterodimerize with these two receptors to regulate dopamine signaling in vitro and in vivo. To determine the consequences of ghsr ablation on brain function, congenic ghsr -/- mice on the C57BL6/J background were subjected to a battery of behavioral tests. We show that the ghsr -/- mice exhibit normal balance, movement, coordination, and pain sensation, outperform ghsr +/+ mice in the Morris water maze, but show deficits in contextual fear conditioning. |
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Authors:
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Rosie G Albarran-Zeckler; Alicia Faruzzi Brantley; Roy G Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-03-31 |
Journal Detail:
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Title: Behavioural brain research Volume: 232 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-28 Completed Date: 2012-09-27 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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The Scripps Research Institute, Florida, Department of Metabolism & Aging, 130 Scripps Way, Jupiter, FL 33458, USA. rzeckler@scripps.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anxiety / psychology Body Weight / genetics, physiology Conditioning, Operant / physiology Fear / psychology Maze Learning / physiology Memory / physiology* Memory Disorders / genetics*, psychology* Mice Mice, Inbred C57BL Mice, Knockout Motor Activity / physiology Pain / psychology Postural Balance / physiology Reaction Time / physiology Receptors, Ghrelin / genetics*, physiology* Space Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG019230-11/AG/NIA NIH HHS; R01-AG19230/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Ghrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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