Document Detail


Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.
MedLine Citation:
PMID:  15699539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GHRP-2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds to the growth hormone (GH) secretagogue receptor. Ghrelin has two major effects, stimulating both GH secretion and appetite/meal initiation. GHRP-2 has been extensively studied for its utility as a growth hormone secretagogue (GHS). Animal studies have shown its effect on food intake. However, whether GHRP-2 can also stimulate appetite in humans when administered acutely is not known. We subcutaneously infused 7 lean, healthy males with GHRP-2 (1 microg/kg/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal. Similar to what has been reported for ghrelin administration, our subjects ate 35.9 +/- 10.9% more when infused with GHRP-2 vs. saline, with every subject increasing their intake even when calculated per kg body weight (136.0 +/- 13.0 kJ/kg [32.5 +/- 3.1 kcal/kg] vs. 101.3 +/- 10.5 kJ/kg [24.2 +/- 2.5 kcal/kg], p = 0.008). The macronutrient composition of consumed food was not different between conditions. As expected, serum GH levels rose significantly during GHRP-2 infusion (AUC 5550 +/- 1090 microg/L/240 min vs. 412 +/- 161 microg/L/240 min, p = 0.003). These data are the first to demonstrate that GHRP-2, like ghrelin, increases food intake, suggesting that GHRP-2 is a valuable tool for investigating ghrelin effects on eating behavior in humans.
Authors:
Blandine Laferrère; Cynthia Abraham; Colleen D Russell; Cyril Y Bowers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-03-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite / drug effects*
Energy Intake / drug effects
Feeding Behavior / drug effects,  physiology
Ghrelin
Growth Hormone-Releasing Hormone / pharmacology
Human Growth Hormone / blood
Humans
Infusions, Intravenous
Male
Oligopeptides / administration & dosage,  pharmacology*
Peptide Hormones / pharmacology*
Placebos
Reference Values
Grant Support
ID/Acronym/Agency:
26687//PHS HHS; DK 02572-01/DK/NIDDK NIH HHS; M01 RR000645/RR/NCRR NIH HHS; M01 RR000645-330955/RR/NCRR NIH HHS; M01 RR000645-340955/RR/NCRR NIH HHS; RR 00645/RR/NCRR NIH HHS; RR 05096/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Oligopeptides; 0/Peptide Hormones; 0/Placebos; 0/growth hormone-releasing peptide-2; 12629-01-5/Human Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone
Comments/Corrections

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