| Growth hormone plus high protein diet promotes adaptation after massive bowel resection in aged rats. | |
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MedLine Citation:
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PMID: 11672992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether GH improves adaptation following massive bowel resection in the aged rat fed on a high protein-content diet. MATERIAL AND METHODS: Seventy-seven male Wistar rats aged 22+/-1 months underwent 80% bowel resection or laparotomy (sham-operation). They were randomly placed into one of eight groups, treated with either growth hormone (1mg/kg/day) or saline, and fed a liquid diet containing either a high or a normal protein content. Intestinal tissue and blood samples were taken seven days after surgery and analysed to measure intestinal mucosal proliferation and mucosal height, as well as plasma levels of IGF-1 and somatostatin. RESULTS: Resection of the small bowel in aged rats remarkably increased villous height and crypt proliferation. Growth hormone did not potentiate the increase in mucosal height and crypt proliferation observed after intestinal resection in aged rats fed a normal protein content diet, but did in those receiving a high-protein diet. Plasma levels of IGF-1 and somatostatin were not modified by surgery or treatment. CONCLUSION: Growth hormone may increase the adaptation of intestinal mucosa in aged rats undergoing massive intestinal resection, but requires an adequate nutritional support with increased amounts of high quality protein. |
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Authors:
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B Fadrique; J M Lopez; R Bermudez; I A Gomez de Segura; I Vazquez; E De Miguel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental gerontology Volume: 36 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-23 Completed Date: 2001-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 1727-37 Citation Subset: IM |
Affiliation:
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Research Unit, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Aging / physiology* Animals Body Weight Cell Division / drug effects Dietary Proteins / administration & dosage*, pharmacology Growth Hormone / pharmacology* Intestinal Mucosa / drug effects Intestines / drug effects, pathology, surgery* Postoperative Period Rats Rats, Wistar Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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