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Growth hormone levels in children and adolescents with epilepsy.
MedLine Citation:
PMID:  20227898     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Patients with epilepsy often complain of symptoms that may be caused by disturbances in their hormonal balance. Disturbances in physical growth has been previously described. The aim of this study was to evaluate the effect of epilepsy and/or anti-epileptic drugs on the physical growth of patients with idiopathic epilepsy, as well as on the growth hormone (GH) and insulin growth factor-1 (IGF-1) status in those patients.
METHODS: The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine. Anthropometric measurements [occipitofrontal circumference, weight, height, body mass index, span, and midarm circumference] were taken. Serum levels of GH before and after provocation with L-dopa and of IGF-1 were assessed. Results were compared to a matched control group.
RESULTS: The height measurements were reduced in patients with epilepsy compared to the controls group. Though weight values were not significantly different, the body mass indices of the patients were significantly higher than controls, especially in patients on valproate therapy. Basal GH levels showed no significantly variation between patients and controls. However, post provocation GH and IGF-1 levels were significantly lower in patients. The type of epilepsy, disease duration, and the degree of seizure control had no significant effect on the studied parameters. In conclusion, physical growth seems to be affected in patients with epilepsy. This may be due to hormonal imbalance as evident by reduced post provocation GH levels and IGF-1 levels in the included group of patients.
Authors:
Hamed A El-Khayat; Gamal S Aly; Hoda Y Tomoum; Rasha M Mamdouh; Abdelmalik K Al-Badani; Essam I Mohamed
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Publication Detail:
Type:  Journal Article     Date:  2010-03-15
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  14     ISSN:  1532-2130     ISO Abbreviation:  Eur. J. Paediatr. Neurol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  508-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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