| Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents. | |
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MedLine Citation:
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PMID: 20956866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical activity plays an important role in tissue anabolism, growth and development, but the mechanisms that link patterns of exercise with tissue anabolism are not completely understood. The effectiveness of physical training depends on the training load and on the individual ability to tolerate it, and an imbalance between the two may lead to under or over-training. Therefore, many efforts have been made to find objective parameters to quantify the balance between training load and the athlete's tolerance. One of the unique features of exercise is that it leads to a simultaneous increase of antagonistic mediators. On the one hand, exercise stimulates anabolic components of the growth hormone (GH) → IGF-1 (insulin-like growth factor-1) axis. On the other hand, exercise elevates catabolic pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α). This emphasizes probably the importance of optimal adaptation to exercise in particularly during adolescence. The very fine balance between the anabolic and inflammatory/catabolic response to exercise will determine the effectiveness of exercise training and the health consequences of exercise. If the anabolic response is stronger, exercise will probably lead ultimately to increased muscle mass and improved fitness. A greater catabolic response, in particularly if persists for long duration, may lead to overtraining. Therefore, changes in the anabolic-catabolic hormonal balance and in circulating inflammatory cytokines can be used by adolescent athletes and/or their coaches to gauge the training intensity in individual and team sports. |
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Authors:
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Dan Nemet; Alon Eliakim |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-10-14 |
Journal Detail:
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Title: Medicine and sport science Volume: 55 ISSN: 0254-5020 ISO Abbreviation: Med Sport Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402440 Medline TA: Med Sport Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 141-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Child Health and Sports Center, Endocrinology clinic, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Kfar-Saba, Israel. dnemet@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Cytokines / blood* Exercise / physiology* Growth Hormone / secretion* Humans Insulin-Like Growth Factor Binding Proteins / blood Insulin-Like Growth Factor I / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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