Document Detail

Growth hormone and insulin-like growth factor-1 in acute myocardial infarction.
MedLine Citation:
PMID:  10973769     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Growth hormone therapy after myocardial infarction improves cardiac function and survival in animals. Beneficial effects in humans are reported from studies where patients with idiopathic dilated cardiomyopathy were treated with growth hormone. We have studied the role of the endogenous growth hormone system in myocardial infarction. METHODS AND RESULTS: Fifty-two consecutive patients with acute myocardial infarction were studied during the first 5 days and at follow-up 6 and 12 weeks later. The time from chest pain onset was used in the analyses. The mean growth hormone level within the first 6 h was nearly three times higher (1.1 +/- 0.2 microg. l(-1)) than on the third day (0.4 +/- 0.05 microg. l(-1), P < 0.0002). It remained higher in patients with higher levels of cardiac enzymes, impaired left ventricular function and intense inflammatory response. Insulin-like growth factor-1 (IGF-1) declined slowly but remained within the normal range throughout the whole study period. Patients who died within 2 years had higher levels of growth hormone and lower levels of IGF-1, indicating growth hormone resistance. Endogenous levels of growth hormone or IGF-1 did not correlate with improvement in left ventricular function at 6 weeks. CONCLUSIONS: The growth hormone axis is stimulated early in acute myocardial infarction, particularly in patients with more severe cardiac damage. Whether treatment with growth hormone can be beneficial for patients with heart failure after myocardial infarction remains to be investigated.
L Friberg; S Werner; G Eggertsen; S Ahnve
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  21     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1547-54     Citation Subset:  IM    
Copyright Information:
Copyright 2000 The European Society of Cardiology.
Department of Cardiology, Karolinska Institutet at Huddinge Hospital, Stockholm, Sweden.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism
Chi-Square Distribution
Human Growth Hormone / blood*
Hydrocortisone / blood
Insulin-Like Growth Factor I / metabolism*
Middle Aged
Myocardial Infarction / blood*,  ultrasonography
Statistics, Nonparametric
Ventricular Dysfunction, Left / blood,  ultrasonography
Reg. No./Substance:
0/Biological Markers; 12629-01-5/Human Growth Hormone; 50-23-7/Hydrocortisone; 67763-96-6/Insulin-Like Growth Factor I; 9007-41-4/C-Reactive Protein
Comment In:
Eur Heart J. 2000 Sep;21(18):1499-501   [PMID:  10973763 ]

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