Document Detail


Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis.
MedLine Citation:
PMID:  16386830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple sclerosis (MS) has several clinically different forms. Whereas the illness progresses slowly in most of the patients, 10% have an aggressively progressive course with fatal outcome without signs of remyelination capability. The process of remyelination depends on numerous interactive factors, including the presence of various growth factors, the most important of which in the adult is insulin growth factor-I (IGF-I). On the other hand, the most powerful postnatal regulator of IGF-I is growth hormone (GH), which also acts as a neuroprotective and an antiapoptotic agent, and has direct influence on myelination. Levels of these growth factors have never been examined in the cerebrospinal fluid (CSF) of patients with MS. The levels of IGF-I and GH were measured in serum and CSF of 46 MS patients and compared with those of 49 patients with no evidence of demyelinating disease. The only positive finding was a deficiency of GH in the CSF of MS patients. The possible implications of those findings in the etiopathogenesis of MS will be discussed.
Authors:
Zdravka Poljakovic; Niko Zurak; Vesna Brinar; Mirko Korsic; Silvio Basic; Sanja Hajnsek
Publication Detail:
Type:  Journal Article     Date:  2006-01-18
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  108     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-25     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Faculty of Medicine, University of Zagreb, REBRO, Hospital Centre, Kispaticeva 12, 10000 Zagreb, Croatia. zdravka.p@mail.inet.hr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Case-Control Studies
Female
Human Growth Hormone / blood*,  cerebrospinal fluid*
Humans
Insulin-Like Growth Factor I / metabolism*
Male
Multiple Sclerosis / blood*,  cerebrospinal fluid*,  etiology
Chemical
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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