| Growth hormone increases ovarian levels of immunoreactive somatomedin C/insulin-like growth factor I in vivo. | |
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MedLine Citation:
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PMID: 3943494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis that GH may affect gonadal function by increasing local levels of the GH-dependent somatomedin C/insulin-like growth factor I (IGF I) was tested. Ovine GH (200 micrograms) was injected into immature, hypophysectomized, estrogen-treated female rats; animals were sacrificed 8 or 12 h later. Renal and ovarian homogenates were acid extracted and chromatographed over Sephadex G-50. Eight h after GH injection, 3.6 to 6.4-fold increases in immunoreactive IGF I (IR-IGF I) levels were observed in either ovarian or renal extracts subjected to acid chromatography. Twelve h after GH treatment, IR-IGF I levels remained elevated, but were lower than after 8 h. In neither case could IR-IGF I levels be accounted for by serum contamination. IR-IGF I eluted with an apparent mol wt near that of synthetic human IGF I in both kidney and ovary. Thus, GH can directly increase ovarian and renal tissue IR-IGF I levels in vivo. Taken with previous observations showing a direct gonadotropin-enhancing effect of IGF I on rat granulosa cells in vitro, our results support the hypothesis that GH may affect ovarian differentiation by inducing the local production or accumulation of IGF I, providing evidence for a novel intraovarian paracrine control mechanism. |
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Authors:
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J B Davoren; A J Hsueh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinology Volume: 118 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-05 Completed Date: 1986-03-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 888-90 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography Female Growth Hormone / pharmacology* Hypophysectomy Insulin-Like Growth Factor I / blood, metabolism* Kidney / drug effects, metabolism Kinetics Ovary / drug effects, metabolism* Rats Rats, Inbred Strains Somatomedins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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