Document Detail

Growth hormone improves mobility and body composition in infants and toddlers with Prader-Willi syndrome.
MedLine Citation:
PMID:  15580194     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the effect of growth hormone (GH) on body composition and motor development in infants and toddlers with Prader-Willi syndrome (PWS). STUDY DESIGN: Twenty-nine subjects with PWS (4-37 months of age) were randomized to GH treatment (1mg/m 2 /day) or observation for 12 months. Percent body fat, lean body mass, and bone mineral density were measured by dual x-ray absorptiometry; energy expenditure was measured by deuterium dilution; and motor constructs of mobility (M) and stability (S) were assessed using the Toddler Infant Motor Evaluation (TIME). RESULTS: GH-treated subjects, compared with controls, demonstrated decreased percent body fat (mean, 22.6% +/- 8.9% vs 28.5% +/- 7.9%; P < .001), increased lean body mass (mean, 9.82 +/- 1.9 kg vs 6.3 +/- 1.9 kg; P < .001), and increased height velocity Z scores (mean, 5. 0 +/- 1.8 vs 1.4 +/- 1.0; P < .001). Patients who began GH before 18 months of age showed higher mobility skill acquisition compared with controls within the same age range (mean increase in raw score, 284 +/- 105 vs 206 +/- 63; P < .05). CONCLUSIONS: GH treatment of infants and toddlers with PWS for 12 months significantly improves body composition and when begun before 18 months of age increases mobility skill acquisition. These results suggest that GH therapy instituted early in life may lessen deterioration of body composition in PWS while also accelerating motor development.
Aaron L Carrel; Victoria Moerchen; Susan E Myers; M Tracy Bekx; Barbara Y Whitman; David B Allen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  145     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-06     Completed Date:  2005-01-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  744-9     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Wisconsin Children's Hospital, Madison, USA.
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MeSH Terms
Body Composition / drug effects*
Carbohydrate Metabolism
Child, Preschool
Energy Metabolism
Human Growth Hormone / therapeutic use*
Lipid Metabolism
Motor Activity / drug effects*
Prader-Willi Syndrome / drug therapy*
Treatment Outcome
Grant Support
Reg. No./Substance:
12629-01-5/Human Growth Hormone
Comment In:
J Pediatr. 2006 Jun;148(6):846; author reply 846-7   [PMID:  16769405 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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