| Growth hormone improves mobility and body composition in infants and toddlers with Prader-Willi syndrome. | |
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MedLine Citation:
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PMID: 15580194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the effect of growth hormone (GH) on body composition and motor development in infants and toddlers with Prader-Willi syndrome (PWS). STUDY DESIGN: Twenty-nine subjects with PWS (4-37 months of age) were randomized to GH treatment (1mg/m 2 /day) or observation for 12 months. Percent body fat, lean body mass, and bone mineral density were measured by dual x-ray absorptiometry; energy expenditure was measured by deuterium dilution; and motor constructs of mobility (M) and stability (S) were assessed using the Toddler Infant Motor Evaluation (TIME). RESULTS: GH-treated subjects, compared with controls, demonstrated decreased percent body fat (mean, 22.6% +/- 8.9% vs 28.5% +/- 7.9%; P < .001), increased lean body mass (mean, 9.82 +/- 1.9 kg vs 6.3 +/- 1.9 kg; P < .001), and increased height velocity Z scores (mean, 5. 0 +/- 1.8 vs 1.4 +/- 1.0; P < .001). Patients who began GH before 18 months of age showed higher mobility skill acquisition compared with controls within the same age range (mean increase in raw score, 284 +/- 105 vs 206 +/- 63; P < .05). CONCLUSIONS: GH treatment of infants and toddlers with PWS for 12 months significantly improves body composition and when begun before 18 months of age increases mobility skill acquisition. These results suggest that GH therapy instituted early in life may lessen deterioration of body composition in PWS while also accelerating motor development. |
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Authors:
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Aaron L Carrel; Victoria Moerchen; Susan E Myers; M Tracy Bekx; Barbara Y Whitman; David B Allen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 145 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-06 Completed Date: 2005-01-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 744-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Wisconsin Children's Hospital, Madison, USA. alcarrel@wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Composition
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drug effects* Carbohydrate Metabolism Child, Preschool Energy Metabolism Female Human Growth Hormone / therapeutic use* Humans Infant Lipid Metabolism Male Motor Activity / drug effects* Prader-Willi Syndrome / drug therapy* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR33186/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2006 Jun;148(6):846; author reply 846-7
[PMID:
16769405
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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