Document Detail


Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment.
MedLine Citation:
PMID:  15194259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in molecular biology have led to the identification of mutations within several novel genes associated with the phenotype of isolated growth hormone deficiency, combined pituitary hormone deficiency, and syndromes such as septo-optic dysplasia. Progress has also been made in terms of the optimum diagnosis of disorders of stature and their treatment. The use of growth hormone for the treatment of adults with growth hormone deficiency and conditions such as Turner's syndrome, Prader-Willi syndrome, intrauterine growth restriction, and chronic renal failure has changed the practice of endocrinology, although cost-benefit implications remain to be established.
Authors:
Mehul Dattani; Michael Preece
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lancet     Volume:  363     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-14     Completed Date:  2004-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  1977-87     Citation Subset:  AIM; IM    
Affiliation:
Institute of Child Health, University College London, London WC1N 1EH, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Height
Gonadotropin-Releasing Hormone / analogs & derivatives,  therapeutic use
Growth / genetics,  physiology
Growth Disorders / drug therapy,  genetics,  physiopathology
Growth Hormone / deficiency*,  genetics,  physiology,  therapeutic use
Humans
Hypothalamo-Hypophyseal System / physiology
Mutation
Pituitary Gland, Anterior / embryology,  physiology
Pituitary Hormones / deficiency
Chemical
Reg. No./Substance:
0/Pituitary Hormones; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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