Document Detail

Growth hormone binding protein in normal and aneuploid pregnancy: a paradoxical decrease in trisomy 18.
MedLine Citation:
PMID:  11467694     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore whether abnormalities in growth hormone binding protein (GHBP) may underlie the growth restriction associated with fetal aneuploidy. DESIGN: A retrospective casecontrol study. SETTING: Monash Medical Centre. Clayton, Victoria, Australia. POPULATION: Twenty-one trisomy 18, and 30 trisomy 21 pregnancies, and 170 chromosomally normal pregnancies at 15-18 weeks of gestation representing three to five controls per case matched for source, gestation and duration of storage. METHODS: GHBP was measured using a ligand immunofunctional assay RESULTS: In the chromosomally normal pregnancies GHBP levels decreased slightly but significantly across the narrow gestational window studied. Compared with controls, levels of GHBP, expressed as median (95% CI) multiples of the median (MoM). in the trisomy 21 pregnancies were similar, 1.0 (0.92-1.39) MoM and 1.27 (1.04-1.50) MoM, respectively; P = 0.061 (Mann-Whitney U test) but were significantly reduced in the trisomy 18 pregnancies, 0.68 (0.5 1-0.84) MoM: P = 0.0014 (Mann-Whitney U test). CONCLUSIONS: These data suggest that decreased levels of maternal growth hormone binding protein, and by implication growth hormone receptor complement, may underlie the early severe growth restriction that is characteristic of trisomy 18.
E M Wallace; D D'Antona; T Veveris-Lowe; J A Crossley; R Barnard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  108     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-24     Completed Date:  2001-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  701-3     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
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MeSH Terms
Carrier Proteins / blood*
Case-Control Studies
Chromosomes, Human, Pair 18 / genetics*
Down Syndrome / blood
Pregnancy Complications* / blood
Retrospective Studies
Reg. No./Substance:
0/Carrier Proteins; 0/somatotropin-binding protein

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