| Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. | |
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MedLine Citation:
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PMID: 2003602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The short-term effects of growth hormone (GH) on skeletal muscle protein synthesis and degradation in normal humans are unknown. We studied seven postabsorptive healthy men (age 18-23 yr) who received GH (0.014 micrograms.kg-1.min-1) via intrabrachial artery infusion for 6 h. The effects of GH on forearm amino acid and glucose balances and on forearm amino acid kinetics [( 3H]Phe and [14C]Leu) were determined after 3 and 6 h of the GH infusion. Forearm deep vein GH rose to 35 +/- 6 ng/ml in response to GH, whereas systemic levels of GH, insulin, and insulin-like growth factor I (IGF-I) were unchanged. Forearm glucose uptake did not change during the study. After 6 h, GH suppressed forearm net release (3 vs. 6 h) of Phe (P less than 0.05), Leu (P less than 0.01), total branched-chain amino acids (P less than 0.025), and essential neutral amino acids (0.05 less than P less than 0.1). The effect on the net balance of Phe and Leu was due to an increase in the tissue uptake for Phe (71%, P less than 0.05) and Leu (37%, P less than 0.005) in the absence of any significant change in release of Phe or Leu from tissue. In the absence of any change in systemic GH, IGF-I, or insulin, these findings suggest that locally infused GH stimulates skeletal muscle protein synthesis. These findings have important physiological implications for both the role of daily GH pulses and the mechanisms through which GH can promote protein anabolism. |
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Authors:
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D A Fryburg; R A Gelfand; E J Barrett |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-12 Completed Date: 1991-04-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E499-504 Citation Subset: IM |
Affiliation:
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Yale Clinical Research Center, New Haven, Connecticut 06510. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / blood Analysis of Variance Blood Glucose Carbon Radioisotopes Forearm Growth Hormone / administration & dosage, pharmacology* Humans Infusions, Intra-Arterial Kinetics Male Muscles / blood supply, drug effects, metabolism* Protein Biosynthesis* Radioisotope Dilution Technique Reference Values Regional Blood Flow / drug effects Tritium |
| Grant Support | |
ID/Acronym/Agency:
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DK-07476/DK/NIDDK NIH HHS; DK-38478/DK/NIDDK NIH HHS; RR-125/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/Carbon Radioisotopes; 10028-17-8/Tritium; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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