Document Detail


Growth failure in the child with inflammatory bowel disease.
MedLine Citation:
PMID:  11726079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Once considered rare in pediatric practice, chronic inflammatory bowel disease (IBD) is now being recognized with increasing frequency in children of all ages. In IBD, growth failure may be the only clinical presentation; it is imperative to perform a detailed history and physical examination to search for other systemic and gastrointestinal manifestations of the disease. IBD can have a significant impact on linear growth, weight gain, and bone mineralization, and can cause delays in the onset of puberty. Delays in growth and sexual development can be early indicators of disease activity, and assessment of growth and development should be performed frequently. Nutritional therapy is important not only to correct undernutrition, but also as therapy for IBD. Delayed puberty can have a significant impact on the self-esteem of the adolescent patient and diminish final adult height. Loss of bone mineral density is especially significant during a period in which the majority of bone accretion is expected to occur. These issues present unique problems to the gastroenterologist caring for a child or adolescent with IBD and require specific types of monitoring and interventions.
Authors:
M Stephens; L A Batres; D Ng; R Baldassano
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Seminars in gastrointestinal disease     Volume:  12     ISSN:  1049-5118     ISO Abbreviation:  Semin. Gastrointest. Dis.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-29     Completed Date:  2002-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9100391     Medline TA:  Semin Gastrointest Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-62     Citation Subset:  IM    
Affiliation:
Division of GI & Nutrition, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Pennsylvania, The University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Monoclonal / therapeutic use
Antimetabolites, Antineoplastic / therapeutic use
Biopsy / methods
Bone Density
Child
Colonoscopy / methods
Crohn Disease / complications,  drug therapy
Female
Gastrointestinal Agents / therapeutic use
Growth Disorders / etiology*
Humans
Inflammatory Bowel Diseases / complications*,  drug therapy
Male
Methotrexate / therapeutic use
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antimetabolites, Antineoplastic; 0/Gastrointestinal Agents; 0/infliximab; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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