Document Detail

Growth factors in mammalian embryogenesis.
MedLine Citation:
PMID:  3878273     Owner:  NLM     Status:  MEDLINE    
Malignant murine embryonal carcinoma (EC) cells have been studied as a means of characterizing the identity and action of growth regulatory molecules in the early postimplantation mouse embryo. The differentiation of EC cells in vitro is accompanied by significant changes in the control of cell proliferation, including the acquisition of dependence on specific exogenous growth factors for cell multiplication. This is at least partly controlled by the developmentally regulated expression of specific growth factor receptors and their intracellular response systems. The development of defined media has allowed the identification of the principal factors required for EC cell proliferation in vitro. These factors are synthesized in vivo by the extra-embryonic tissues of the developing embryo and by the differentiated progeny of EC cells in vitro. EC cells secrete a potent growth factor (embryonal carcinoma-derived growth factor, ECDGF) which has been purified and partly characterized. ECDGF induces proliferation of the differentiated progeny of EC cells and specific normal embryonic cell types in vitro, suggesting that ECDGF may act as an embryonic growth factor in vivo. Together these findings suggest that proliferation in the embryo may be controlled by reciprocal interaction between primitive ectoderm cells and their differentiated derivatives, mediated by the developmentally regulated expression of specific soluble growth factors.
J K Heath; A R Rees
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  116     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1985  
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  3-22     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation*
Cell Division
Cells, Cultured
Embryo, Mammalian / analysis*
Embryonal Carcinoma Stem Cells
Epidermal Growth Factor / analysis,  pharmacology
Growth Substances / analysis*,  pharmacology
Insulin-Like Growth Factor I / analysis,  pharmacology
Molecular Weight
Neoplastic Stem Cells / analysis*,  pathology
Reg. No./Substance:
0/Growth Substances; 62229-50-9/Epidermal Growth Factor; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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