| Growth factors and cell therapy in myocardial regeneration. | |
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MedLine Citation:
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PMID: 18206905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite significant advances in myocardial revascularization and reperfusion, coronary artery disease and subsequently myocardial infarction, are the leading cause of morbidity and mortality in the US. Thus one of the main goals in the treatment of myocardial ischemia is the development of effective therapy for angiogenesis. The first evidence is the demonstration of alleviation of myocardial ischemia and increased number of collateral blood vessels in the early 1990s following intra-coronary administration of basic fibroblast growth factor protein in dog. Multiple animal studies, has confirmed the concept of stimulation of collateral development by pharmacological and molecular means. This includes direct delivery of growth factors into the ischemic target tissues, or of genes that encode for synthesis of growth factors by target tissues. Both cell therapy and gene therapy have proven to be effective to promote neovascularization in various animal models. Cell therapy alone is proven to be beneficial however the combination of cell and gene therapy (growth factors) may enhance therapeutic neovascularization. Thus clinically relevant, combined strategy could be an excellent strategy for treating patients with myocardial infarction. |
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Authors:
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Nilanjana Maulik; Mahesh Thirunavukkarasu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-12-07 |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 44 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 219-27 Citation Subset: IM |
Affiliation:
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Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Medical Center, 263 Farmington Avenue, Farmington, CT 06030-1110, USA. nmaulik@neuron.uchc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Intercellular Signaling Peptides and Proteins / metabolism*, pharmacology Myocardium / metabolism* Neovascularization, Physiologic / drug effects Regeneration* / drug effects Tissue Therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL 56803/HL/NHLBI NIH HHS; HL 69910/HL/NHLBI NIH HHS; HL 85804/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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