| Growth factor release by smooth muscle cells is dependent on haemodynamic factors. | |
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MedLine Citation:
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PMID: 1451820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormal proliferation of smooth muscle cells (SMCs) is a key event in the development of the atherosclerotic plaque. The early atherosclerotic plaque localises preferentially in areas of flow separation. The basic mechanisms which correlate haemodynamic forces and atherosclerotic plaque formation are not known. Bovine arterial SMCs were subjected to increasing levels of shear stress for 24 h in an in vitro system. The control group was subjected to similar incubation conditions without flow. SMCs subjected to shear stress released a higher quantity of mitogens, including a platelet derived growth factor (PDGF)-like substance. This mitogenic activity was partially reduced (30%, p < 0.01) by an excess of monospecific anti-PDGF antibody. The release of mitogens was proportional to the level of shear stress and was still evident 24 h after flow cessation. In conclusion, shear stress influences the release of mitogens; this might represent a mechanism which links haemodynamic forces and atherosclerotic plaque formation. |
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Authors:
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A V Sterpetti; A Cucina; F Napoli; H Shafer; A Cavallaro; L S D'Angelo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of vascular surgery Volume: 6 ISSN: 0950-821X ISO Abbreviation: Eur J Vasc Surg Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709440 Medline TA: Eur J Vasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 636-8 Citation Subset: IM |
Affiliation:
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I Istituto Clinica Chirurgica, University of Rome La Sapienza, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / cytology Cattle Cell Division / physiology Cells, Cultured Culture Media Enzyme-Linked Immunosorbent Assay Hemodynamics / physiology* Models, Cardiovascular Muscle, Smooth, Vascular / physiology* Platelet-Derived Growth Factor / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Platelet-Derived Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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