Document Detail

Growth factor release by smooth muscle cells is dependent on haemodynamic factors.
MedLine Citation:
PMID:  1451820     Owner:  NLM     Status:  MEDLINE    
Abnormal proliferation of smooth muscle cells (SMCs) is a key event in the development of the atherosclerotic plaque. The early atherosclerotic plaque localises preferentially in areas of flow separation. The basic mechanisms which correlate haemodynamic forces and atherosclerotic plaque formation are not known. Bovine arterial SMCs were subjected to increasing levels of shear stress for 24 h in an in vitro system. The control group was subjected to similar incubation conditions without flow. SMCs subjected to shear stress released a higher quantity of mitogens, including a platelet derived growth factor (PDGF)-like substance. This mitogenic activity was partially reduced (30%, p < 0.01) by an excess of monospecific anti-PDGF antibody. The release of mitogens was proportional to the level of shear stress and was still evident 24 h after flow cessation. In conclusion, shear stress influences the release of mitogens; this might represent a mechanism which links haemodynamic forces and atherosclerotic plaque formation.
A V Sterpetti; A Cucina; F Napoli; H Shafer; A Cavallaro; L S D'Angelo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  6     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  636-8     Citation Subset:  IM    
I Istituto Clinica Chirurgica, University of Rome La Sapienza, Italy.
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MeSH Terms
Aorta, Thoracic / cytology
Cell Division / physiology
Cells, Cultured
Culture Media
Enzyme-Linked Immunosorbent Assay
Hemodynamics / physiology*
Models, Cardiovascular
Muscle, Smooth, Vascular / physiology*
Platelet-Derived Growth Factor / metabolism*
Reg. No./Substance:
0/Culture Media; 0/Platelet-Derived Growth Factor

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