| Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. | |
| | |
MedLine Citation:
|
PMID: 21360016 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Growth factor Midkine (MK), which expresses on endothelial cells and renal proximal tubules, has been implicated in inflammation-related kidney diseases such as ischemic reperfusion-induced tubulointerstitial injury and diabetic nephropathy. The biological actions of MK are elicited through its chemotactic activity and chemokine-driven inflammatory pathway. Post-infectious glomerulonephritis is caused by the deposition of immune complexes into glomeruli by infiltrating a number of inflammatory cells. Therefore, we investigated whether MK might be involved in the pathogenesis of acute glomerulonephritis. METHODS: We induced endocapillary proliferative glomerulonephritis in 129/SV mice using intraperitoneal injections of a large amount of protein. RESULTS: In contrast to mice deficient in MK (Mdk (-/-)), Mdk (+/+) mice induced by protein overload demonstrated more diffuse cellular proliferation in the mesangial areas and capillary lumens, eventually leading to glomerular damage and tubulointerstitial injury. This pathological observation could be attributable to neutrophil infiltration through the chemotaxis and stimulation of the MK-macrophage inflammatory protein (MIP)-2 pathway, but appeared to be due to the MK-related immunoglobulin (Ig)G deposition and C3 activation. These findings are often seen in infectious-related glomerular injury. Furthermore, the profile of MK expression was strongly consistent with that of glomerular damage and tubulointersititial injury. CONCLUSION: This study might provide a new insight into understanding the deleterious role of MK in endocapillary proliferative glomerulonephritis induced by protein overload. |
| | |
Authors:
|
Kiyonari Kato; Tomoki Kosugi; Waichi Sato; Hanayo Arata-Kawai; Takenori Ozaki; Naotake Tsuboi; Isao Ito; Hideo Tawada; Yukio Yuzawa; Seiichi Matsuo; Kenji Kadomatsu; Shoichi Maruyama |
Related Documents
:
|
11726196 - Real time rt-pcr shows correlation between retinoid-induced apoptosis and ngf-r mrna le... 17764066 - Induction of apoptosis and regulation of the mapk pathway by ursolic acid in human leuk... 14592536 - Distinct role and functional mode of tr3 and raralpha in mediating atra-induced signall... 22129506 - Polyarteritis nodosa associated with essential mixed cryglobulinemia revealed by subara... 21439806 - Serum cytokines markers in toluene diisocyanate-induced asthma. 21803656 - Nlrs in immune privileged sites. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-1 |
Journal Detail:
|
Title: Clinical and experimental nephrology Volume: - ISSN: 1437-7799 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered monocyte-derived dendritic cell function in patients on hemodialysis: a culprit for underlyi...
Next Document: A More Secure Authentication Scheme for Telecare Medicine Information Systems.