| Growth and differentiation of PC6 cells: the effects of pulsed electromagnetic fields (PEMF). | |
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MedLine Citation:
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PMID: 11298388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies in our laboratory showed that neurite outgrowth in vitro and nerve regeneration in vivo were stimulated by 2 Hz, 0.3 mT (3 G) pulsed electromagnetic fields (PEMF). To learn more about the effects of PEMF on nerve cells, we exposed PC6 cells, a standard neuronal-like cell model, to the same pulsed electromagnetic fields for 2 h/day for 2 days and asked whether two different cell processes, proliferation and differentiation, were affected. The cells were also treated with a differentiating agent, nerve growth factor (NGF), to further define any interactive effects. We found that proliferation was unaffected by either PEMF or NGF alone or in combination. Differentiation, expressed as neurite outgrowth, was strongly upregulated with NGF, but this NGF response was significantly depressed in cells treated with PEMF. |
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Authors:
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J P Shah; P Midkiff; P C Brandt; B F Sisken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioelectromagnetics Volume: 22 ISSN: 0197-8462 ISO Abbreviation: Bioelectromagnetics Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-12 Completed Date: 2001-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008281 Medline TA: Bioelectromagnetics Country: United States |
Other Details:
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Languages: eng Pagination: 267-71 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Wiley-Liss, Inc. |
Affiliation:
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Center for Biomedical Engineering and Department of Anatomy and Neurobiology, University of Kentucky, Lexington 40506-0070, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects, radiation effects* Cell Division / drug effects, radiation effects* Electromagnetic Fields* Kinetics Models, Neurological Nerve Growth Factor / pharmacology Neurons / cytology*, drug effects, radiation effects PC12 Cells Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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9061-61-4/Nerve Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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