Document Detail


Growth and development of Haemonchus contortus in jirds, Meriones unguiculatus.
MedLine Citation:
PMID:  1597794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth and development of Haemonchus contortus were examined in jirds and were compared to these processes in lambs. Number, sex, size, and stage of development were determined for worms recovered at necropsy at various times postinoculation (PI) from immunosuppressed jirds inoculated with approximately 1,000 exsheathed infective larvae (L3) of H. contortus. In addition, gastric tissue samples from jirds were examined histologically. Parallel studies were done in lambs inoculated with approximately 7,500 L3. Typically, 5-30% of the inoculum established and survived in jirds at reasonably stable numbers to day 14 PI. By day 21 PI, worm numbers in jirds decreased dramatically. Although the parasite was similar in size and development on day 4 PI in jirds and lambs, from day 7 PI on, worms were significantly smaller and less developed in jirds. On histological examination, the parasite was found only in the glandular portion of the stomach of jirds (anatomically similar to its predilection site in the abomasum of lambs), and histological changes were consistent for both host species. Although growth and development of H. contortus are slower and incomplete in jirds, the parasite establishes, grows, and develops (at anatomically comparable sites in both hosts) in this model. Thus, the model appears to provide a useful laboratory host to study H. contortus.
Authors:
G A Conder; S S Johnson; A D Hall; M W Fleming; M D Mills; P M Guimond
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of parasitology     Volume:  78     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-06     Completed Date:  1992-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-7     Citation Subset:  IM    
Affiliation:
Parasitology Research, Upjohn Laboratories, Kalamazoo, Michigan 49001.
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MeSH Terms
Descriptor/Qualifier:
Abomasum / parasitology
Animals
Disease Models, Animal*
Female
Gastric Mucosa / parasitology
Gerbillinae / parasitology*
Haemonchiasis / parasitology,  veterinary*
Haemonchus / growth & development*
Immunosuppression
Male
Random Allocation
Sheep
Sheep Diseases / parasitology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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