Document Detail

Growth and development of Andean high altitude residents.
MedLine Citation:
PMID:  16764525     Owner:  NLM     Status:  MEDLINE    
Growth and development under conditions of chronic hypoxia result in a different pattern of growth in Andean highlanders than in lowlanders. Growth at high altitude results in a small (1 to 4 cm) delay in linear growth, with most, if not all, of the delay probably established at or soon after birth. It also results in an enhancement of lung volumes, particularly residual volume, which is 70%-80% larger in highland than lowland children, on average, with the magnitude of the increase being positively related to age. In addition, growth and development under conditions of chronic hypoxia result in a blunted ventilatory response to hypoxia, a 4% to 5% reduction in Sa(O2), and a substantial increase in pulmonary diffusing capacity. Andean highlanders have V(O2 max) similar to that of lowlanders at low altitude, suggesting that they have successfully adapted to their hypoxic environment. It is likely that both developmental and genetic factors influence most, if not all, components of the cardiorespiratory system of Andean highlanders, but the relative importance of each is not clear.
Lawrence P Greksa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  7     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-24     Citation Subset:  IM; S    
Department of Anthropology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Acclimatization / physiology*
Altitude Sickness / complications*
Body Height / physiology
Body Size / physiology*
Body Weight / physiology
Child Development / physiology*
Growth Disorders / etiology*
Health Status
Indians, South American
Lung / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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