Document Detail

Growth curves of Staphylococcus aureus, Candida albicans, and Moraxella osloensis in propofol and other media.
MedLine Citation:
PMID:  1534525     Owner:  NLM     Status:  MEDLINE    
Propofol, 2,6 diisopropylphenol, in an emulsion formulation (Diprivan), has been associated with postsurgical infections caused by Staphylococcus aureus, Moraxella osloensis and Candida albicans. These organisms were individually inoculated into each of the following media: (1) the emulsion preparation of propofol, (2) Intralipid 10%, (3) pure 2,6 diisopropylphenol, and (4) trypticase soy broth (TSB). The organisms were incubated and subcultured hourly for eight hours at room temperature. Propofol supported the growth of all three organisms, but for S. aureus and M. osloenis, the growth rate was slower in propofol than in TSB (P less than 0.05). There was no difference between the growth rate of any organism in propofol than in Intralipid 10%. The authors conclude that propofol, in the emulsion formulation, supports bacterial growth and, therefore, must be prepared for administration in an aseptic manner. Also, by administering propofol soon after preparation, the risk of introduction of a significant inoculum to the patient will be reduced.
M Tessler; A Dascal; S Gioseffini; M Miller; J Mendelson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  39     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-07     Completed Date:  1992-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  509-11     Citation Subset:  IM    
Department of Anaesthesia and Medicine, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Candida albicans / growth & development*
Colony Count, Microbial
Culture Media
Fat Emulsions, Intravenous
Moraxella / growth & development*
Protein Hydrolysates
Regression Analysis
Staphylococcus aureus / growth & development*
Reg. No./Substance:
0/Caseins; 0/Culture Media; 0/Fat Emulsions, Intravenous; 0/Protein Hydrolysates; 0/trypticase-soy broth; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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