Document Detail

Growth cones utilize both widespread and local directional cues in the zebrafish brain.
MedLine Citation:
PMID:  10694428     Owner:  NLM     Status:  MEDLINE    
The distribution of cues that provide directional information for specific growth cones in the zebrafish brain was functionally assayed by transplanting epiphysial neurons to ectopic locations in the embryonic brain followed by determining the pathways taken by the donor axons. Epiphysial axons normally first extend ventrally from their position in the dorsal diencephalon and then turn and extend anteriorly in the ventral diencephalon. When transplanted to ectopic sites at other axial levels of the brain, where in principle the axons could extend in any direction, epiphysial axons consistently extended ventrally. Furthermore, following initial ventral extension ectopic epiphysial axons turned randomly in the anterior and posterior directions. These results suggest that the cues for ventral extension are widely distributed along the rostrocaudal axis of the zebrafish brain, but the cues for subsequent anterior extension are restricted to the site where the epiphysial axons normally turn longitudinally.
J P Kanki; J Y Kuwada
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  219     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-03     Completed Date:  2000-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-72     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109-1048, USA.
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MeSH Terms
Axons / ultrastructure
Brain / embryology*,  ultrastructure
Gene Expression Regulation, Developmental
Growth Cones / ultrastructure*
Homeodomain Proteins / genetics
In Situ Hybridization
Intracellular Signaling Peptides and Proteins
Nerve Tissue Proteins / genetics
Neural Pathways / embryology
Neurons / transplantation
Transforming Growth Factor beta / genetics
Zebrafish / embryology*,  genetics
Zebrafish Proteins
Grant Support
Reg. No./Substance:
0/Homeodomain Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Transforming Growth Factor beta; 0/Zebrafish Proteins; 0/insulin gene enhancer binding protein Isl-1; 0/ndr2 protein, zebrafish

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