| Growth cones utilize both widespread and local directional cues in the zebrafish brain. | |
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MedLine Citation:
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PMID: 10694428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of cues that provide directional information for specific growth cones in the zebrafish brain was functionally assayed by transplanting epiphysial neurons to ectopic locations in the embryonic brain followed by determining the pathways taken by the donor axons. Epiphysial axons normally first extend ventrally from their position in the dorsal diencephalon and then turn and extend anteriorly in the ventral diencephalon. When transplanted to ectopic sites at other axial levels of the brain, where in principle the axons could extend in any direction, epiphysial axons consistently extended ventrally. Furthermore, following initial ventral extension ectopic epiphysial axons turned randomly in the anterior and posterior directions. These results suggest that the cues for ventral extension are widely distributed along the rostrocaudal axis of the zebrafish brain, but the cues for subsequent anterior extension are restricted to the site where the epiphysial axons normally turn longitudinally. |
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Authors:
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J P Kanki; J Y Kuwada |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental biology Volume: 219 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-03 Completed Date: 2000-04-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 364-72 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109-1048, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / ultrastructure Brain / embryology*, ultrastructure Gene Expression Regulation, Developmental Growth Cones / ultrastructure* Homeodomain Proteins / genetics In Situ Hybridization Intracellular Signaling Peptides and Proteins Mutation Nerve Tissue Proteins / genetics Neural Pathways / embryology Neurons / transplantation Transforming Growth Factor beta / genetics Zebrafish / embryology*, genetics Zebrafish Proteins |
| Grant Support | |
ID/Acronym/Agency:
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NS36587/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Transforming Growth Factor beta; 0/Zebrafish Proteins; 0/insulin gene enhancer binding protein Isl-1; 0/ndr2 protein, zebrafish |
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