| Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. | |
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MedLine Citation:
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PMID: 9856457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More than half of the dorsal root ganglion (DRG) neurons are lost by excessive cell death coinciding with precursor proliferation and cell cycle exit in neurotrophin-3 null mutant (NT-3-/-) mice. We find that in the absence of NT-3, sensory precursor cells fail to arrest the cell cycle, override the G1 phase restriction point, and die by apoptosis in S phase, which can be prevented in vivo by a cell cycle blocker. Uncoordinated cell cycle reentry is preceded by a failure of nuclear N-myc downregulation and is paralleled by the activation of the full repertoire of G1 and S phase cell cycle proteins required for cell cycle entry. Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3. |
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Authors:
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W M ElShamy; L K Fridvall; P Ernfors |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 21 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-04 Completed Date: 1999-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1003-15 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / genetics G1 Phase / genetics* Mice Mice, Inbred BALB C Mice, Knockout Nerve Growth Factors / deficiency*, genetics* Neurons, Afferent / pathology* Neurotrophin 3 S Phase / genetics* Stem Cells / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/Neurotrophin 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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