Document Detail

Growth standards of infants with Prader-Willi syndrome.
MedLine Citation:
PMID:  21402637     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non-growth hormone-treated white infants (boys and girls) with Prader-Willi syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS.
METHODS: Anthropometric measures (N = 758) were obtained according to standard methods and analyzed from 186 non-growth hormone-treated white infants (108 boys and 78 girls) with PWS between 0 and 36 months of age. Standardized growth curves were developed and the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated by using the LMS (refers to λ, μ, and σ) smoothing procedure method for weight, length, head circumference, weight/length, and BMI along with the normative 50th percentile using Centers for Disease Control and Prevention national growth data from 2003. The data were plotted for comparison purposes.
RESULTS: Five separate standardized growth curves (weight, length, head circumference, weight/length, and BMI) representing 7 percentile ranges were developed from 186 non-growth hormone-treated white male and female infants with PWS aged 0 to 36 months, and the normative 50th percentile was plotted on each standardized infant growth curve.
CONCLUSIONS: We encourage the use of these growth standards when examining infants with PWS and evaluating growth for comparison purposes, monitoring for growth patterns, nutritional assessment, and recording responses to growth hormone therapy, commonly used in infants and children with PWS.
Merlin G Butler; Jennifer Sturich; Jaehoon Lee; Susan E Myers; Barbara Y Whitman; June-Anne Gold; Virginia Kimonis; Ann Scheimann; Norma Terrazas; Daniel J Driscoll
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-14
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-05-31     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-95     Citation Subset:  AIM; IM    
Department of Psychiatry, Kansas University Medical Center, 3901 Rainbow Blvd, MS 4015, Kansas City, KS 66160, USA.
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MeSH Terms
Age Factors
Body Height / drug effects,  physiology
Body Mass Index
Body Weight / drug effects,  physiology
Child, Preschool
Growth Charts*
Human Growth Hormone / therapeutic use
Nutrition Assessment
Prader-Willi Syndrome / drug therapy,  physiopathology*
Recombinant Proteins / therapeutic use
Reference Values
Sex Factors
Grant Support
Reg. No./Substance:
0/Recombinant Proteins; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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