Document Detail

Growth and Neurodevelopment in Extremely Low-Birth-Weight Neonates Exposed to Postnatal Steroid Therapy.
MedLine Citation:
PMID:  21512966     Owner:  NLM     Status:  Publisher    
We compared postnatal growth and neurodevelopment in extremely low-birth-weight (<1000 g) neonates who did or did not receive postnatal steroid (PNS) therapy for bronchopulmonary dysplasia (BPD). One hundred seventy-three neonates with Bayley Scales of Infant Development II (BSID II) testing performed at 18- to 22-month adjusted age were studied. Growth parameters and BSID II scales were compared among three groups: group I, no BPD; group II, BPD, no PNS; group III, BPD and PNS exposure. A subset of 77 neonates' growth parameters were retrieved at 12-month adjusted age. Psychomotor Development Index (PDI) and Mental Development Index (MDI) scales were lower in group III versus groups I and II. Growth velocity (GV) was lower in group III versus group I and II during the initial hospital stay. In the subset, GV from birth to 1-year adjusted age and weight, length, and head circumference determined at 1-year adjusted age were similar among the groups. Multivariate analysis revealed a significant effect of group membership and cystic periventricular leukomalacia on PDI. These results suggest that a deleterious effect of PNS therapy on neurodevelopment can occur by a mechanism that does not impair overall growth or growth of head circumference.
Judy L Leflore; William D Engle
Related Documents :
24358456 - Streptococcus pneumoniae non-susceptibility and outpatient antimicrobial prescribing ra...
22959736 - The great unravelling: chromatin as a modulator of the aging process.
23869756 - A re-analysis of the long-term effects on life expectancy of the great finnish famine o...
24234046 - Stimulating basic reading processes using auditory discrimination in depth.
21526656 - Influence of sociodemographic factors on helicobacter pylori prevalence variability amo...
629676 - Retinal involvement in thoracic-pelvic-phalangeal dystrophy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  American journal of perinatology     Volume:  -     ISSN:  1098-8785     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Thieme Medical Publishers.
Department of Pediatrics, School of Nursing, The University of Texas at Arlington, Arlington.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mel...
Next Document:  Physiotherapy Home Exercise Program for Haemophiliacs.