Document Detail

Growth of lung parenchyma in infants and toddlers with chronic lung disease of infancy.
MedLine Citation:
PMID:  20133928     Owner:  NLM     Status:  MEDLINE    
RATIONALE: The clinical pathology describing infants with chronic lung disease of infancy (CLDI) has been limited and obtained primarily from infants with severe lung disease, who either died or required lung biopsy. As lung tissue from clinically stable outpatients is not available, physiological measurements offer the potential to increase our understanding of the pulmonary pathophysiology of this disease.
OBJECTIVES: We hypothesized that if premature birth and the development of CLDI result in disruption of alveolar development, then infants and toddlers with CLDI would have a lower pulmonary diffusing capacity relative to their alveolar volume compared with full-term control subjects.
METHODS: We measured pulmonary diffusing capacity and alveolar volume, using a single breath-hold maneuver at elevated lung volume. Subjects with chronic lung disease of infancy (23-29 wk of gestation; n = 39) were compared with full-term control subjects (n = 61) at corrected ages of 11.6 (4.8-17.0) and 13.6 (3.2-33) months, respectively.
MEASUREMENTS AND MAIN RESULTS: Alveolar volume and pulmonary diffusing capacity increased with increasing body length for both groups. After adjusting for body length, subjects with CLDI had significantly lower pulmonary diffusing capacity (2.88 vs. 3.23 ml/min/mm Hg; P = 0.0004), but no difference in volume (545 vs. 555 ml; P = 0.58).
CONCLUSIONS: Infants and toddlers with CLDI have decreased pulmonary diffusing capacity, but normal alveolar volume. These physiological findings are consistent with the morphometric data obtained from subjects with severe lung disease, which suggests an impairment of alveolar development after very premature birth.
Juan E Balinotti; Valentina C Chakr; Christina Tiller; Risa Kimmel; Cathy Coates; Jeffrey Kisling; Zhangsheng Yu; James Nguyen; Robert S Tepper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-04
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  181     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-06-09     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-7     Citation Subset:  AIM; IM    
Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202-5225, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / pathology*,  physiopathology
Case-Control Studies
Chronic Disease
Gestational Age
Infant, Newborn
Infant, Premature
Pulmonary Alveoli / growth & development*,  pathology*,  physiopathology
Pulmonary Diffusing Capacity
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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