| Growth of lung parenchyma in infants and toddlers with chronic lung disease of infancy. | |
MedLine Citation:
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PMID: 20133928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: The clinical pathology describing infants with chronic lung disease of infancy (CLDI) has been limited and obtained primarily from infants with severe lung disease, who either died or required lung biopsy. As lung tissue from clinically stable outpatients is not available, physiological measurements offer the potential to increase our understanding of the pulmonary pathophysiology of this disease. OBJECTIVES: We hypothesized that if premature birth and the development of CLDI result in disruption of alveolar development, then infants and toddlers with CLDI would have a lower pulmonary diffusing capacity relative to their alveolar volume compared with full-term control subjects. METHODS: We measured pulmonary diffusing capacity and alveolar volume, using a single breath-hold maneuver at elevated lung volume. Subjects with chronic lung disease of infancy (23-29 wk of gestation; n = 39) were compared with full-term control subjects (n = 61) at corrected ages of 11.6 (4.8-17.0) and 13.6 (3.2-33) months, respectively. MEASUREMENTS AND MAIN RESULTS: Alveolar volume and pulmonary diffusing capacity increased with increasing body length for both groups. After adjusting for body length, subjects with CLDI had significantly lower pulmonary diffusing capacity (2.88 vs. 3.23 ml/min/mm Hg; P = 0.0004), but no difference in volume (545 vs. 555 ml; P = 0.58). CONCLUSIONS: Infants and toddlers with CLDI have decreased pulmonary diffusing capacity, but normal alveolar volume. These physiological findings are consistent with the morphometric data obtained from subjects with severe lung disease, which suggests an impairment of alveolar development after very premature birth. |
Authors:
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Juan E Balinotti; Valentina C Chakr; Christina Tiller; Risa Kimmel; Cathy Coates; Jeffrey Kisling; Zhangsheng Yu; James Nguyen; Robert S Tepper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-04 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 181 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-06-09 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1093-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202-5225, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia
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pathology*,
physiopathology Case-Control Studies Chronic Disease Female Gestational Age Humans Infant Infant, Newborn Infant, Premature Male Pulmonary Alveoli / growth & development*, pathology*, physiopathology Pulmonary Diffusing Capacity |
| Grant Support | |
ID/Acronym/Agency:
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HL054062/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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