Document Detail


Growth hormone administration: is it safe and effective for athletic performance.
MedLine Citation:
PMID:  20122446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human growth hormone (GH) is widely abused by athletes; however, there is little evidence that GH improves physical performance. Replacement of GH in GH deficiency improves some aspects of exercise capacity. There is evidence for a protein anabolic effect of GH in healthy adults and for increased lean body mass following GH, although fluid retention likely contributes to this increase. The evidence suggests that muscle strength, power, and aerobic exercise capacity are not enhanced by GH administration, however GH may improve anaerobic exercise capacity. There are risks of adverse effects of long-term abuse of GH. Sustained abuse of GH may lead to a state mimicking acromegaly, a condition with increased morbidity and mortality.
Authors:
Vita Birzniece; Anne E Nelson; Ken K Y Ho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-23, vii     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerobiosis
Anaerobiosis
Athletic Performance*
Body Composition
Doping in Sports / legislation & jurisprudence*
Exercise / physiology
Human Growth Hormone / administration & dosage*,  adverse effects,  deficiency*
Humans
Muscle Strength
Oxygen Consumption
Proteins / metabolism
Risk Factors
Chemical
Reg. No./Substance:
0/Proteins; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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