| Growth factors in induction of epithelial-mesenchymal transition and metastasis. | |
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MedLine Citation:
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PMID: 21051862 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies. |
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Authors:
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Nur Akmarina B M Said; Elizabeth D Williams |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-03 |
Journal Detail:
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Title: Cells, tissues, organs Volume: 193 ISSN: 1422-6421 ISO Abbreviation: Cells Tissues Organs (Print) Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883360 Medline TA: Cells Tissues Organs Country: Switzerland |
Other Details:
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Languages: eng Pagination: 85-97 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Melbourne, VIC, Australia. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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