Document Detail


Growth Factors and Neuropathic Pain.
MedLine Citation:
PMID:  21327569     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A treatment for neuropathic pain is an important unmet medical need because this pain often is refractory to many medical interventions. An important element in the development of neuropathic pain is a dysfunction in the activity of peripheral nerves. Because neurotrophic factors affect nerve development and maintenance, modulating the activity of these factors can alter neuronal pathophysiology and produce a disease-modifying effect. Blocking the activity of nerve growth factor or enhancing the activity of either glial-derived neurotrophic factor or artemin has shown potential for normalizing neuronal activity and attenuating signs of neuropathic pain in animal models and clinical studies. This article discusses the role of these factors in neuropathic pain and the implications for the development of novel therapeutics.
Authors:
Michael H Ossipov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-16
Journal Detail:
Title:  Current pain and headache reports     Volume:  -     ISSN:  1534-3081     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100970666     Medline TA:  Curr Pain Headache Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, PO Box 245050, Tucson, AZ, 85724-5050, USA, michaelo@email.arizona.edu.
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