Document Detail


Growth factors, muscle function, and doping.
MedLine Citation:
PMID:  20122457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article discusses the inevitable use of growth factors for enhancing muscle strength and athletic performance. Much effort has been expended on developing a treatment of muscle wasting associated with a range of diseases and aging. Frailty in the aging population is a major socioeconomic and medical problem. Emerging molecular techniques have made it possible to gain a better understanding of the growth factor genes and how they are activated by physical activity. The ways that misuse of growth factors may be detected and verified in athletes and future challenges for detecting manipulation of signaling pathways are discussed.
Authors:
Geoffrey Goldspink; Barbara Wessner; Harald Tschan; Norbert Bachl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-81, xi     Citation Subset:  IM    
Copyright Information:
Copyright 2010. Published by Elsevier Inc.
Affiliation:
Department of Surgery, University College Medical School, University of London, London, England, UK. gb.goldspink@btinternet.com
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MeSH Terms
Descriptor/Qualifier:
Anabolic Agents / administration & dosage
Animals
Athletic Performance
Doping in Sports*
Growth Substances* / administration & dosage,  genetics,  physiology
Human Growth Hormone / administration & dosage,  physiology
Humans
Hypertrophy
Insulin-Like Growth Factor I / administration & dosage,  genetics,  physiology
Muscle Proteins / biosynthesis,  metabolism
Muscle Strength / physiology
Muscle, Skeletal / pathology,  physiology*
Myostatin / antagonists & inhibitors,  genetics
Protein Isoforms / genetics,  physiology
Receptor, IGF Type 1 / physiology
Stress, Mechanical
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Growth Substances; 0/Muscle Proteins; 0/Myostatin; 0/Protein Isoforms; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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