| Growth factors, muscle function, and doping. | |
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MedLine Citation:
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PMID: 20122457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article discusses the inevitable use of growth factors for enhancing muscle strength and athletic performance. Much effort has been expended on developing a treatment of muscle wasting associated with a range of diseases and aging. Frailty in the aging population is a major socioeconomic and medical problem. Emerging molecular techniques have made it possible to gain a better understanding of the growth factor genes and how they are activated by physical activity. The ways that misuse of growth factors may be detected and verified in athletes and future challenges for detecting manipulation of signaling pathways are discussed. |
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Authors:
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Geoffrey Goldspink; Barbara Wessner; Harald Tschan; Norbert Bachl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 39 ISSN: 1558-4410 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 169-81, xi Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Inc. |
Affiliation:
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Department of Surgery, University College Medical School, University of London, London, England, UK. gb.goldspink@btinternet.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents
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administration & dosage Animals Athletic Performance Doping in Sports* Growth Substances* / administration & dosage, genetics, physiology Human Growth Hormone / administration & dosage, physiology Humans Hypertrophy Insulin-Like Growth Factor I / administration & dosage, genetics, physiology Muscle Proteins / biosynthesis, metabolism Muscle Strength / physiology Muscle, Skeletal / pathology, physiology* Myostatin / antagonists & inhibitors, genetics Protein Isoforms / genetics, physiology Receptor, IGF Type 1 / physiology Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Growth Substances; 0/Muscle Proteins; 0/Myostatin; 0/Protein Isoforms; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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