Document Detail

Growth and body composition of human milk-fed premature infants provided with extra energy and nutrients early after hospital discharge: 1-year follow-up.
MedLine Citation:
PMID:  19633578     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Human milk (HM) is the optimal source of nutrition for premature infants; however, it is unclear whether HM alone is sufficient to meet their elevated nutritional requirements early after hospital discharge. We previously reported that premature infants (750-1800 g birth weight) fed HM containing extra nutrients for 12 weeks after discharge had dietary intakes closer to recommended levels and grew more rapidly than those fed HM alone. The objectives of the present article are to examine the impact of this intervention on bone mineralization, body composition, and HM use up to 1 year. Data are also presented on general developmental level at 18-month corrected age (CA). PATIENTS AND METHODS: At discharge, predominantly HM-fed infants were randomized to receive for 12 weeks either approximately half of their feedings containing a multinutrient fortifier (intervention, n=19) or all of their feedings as HM alone (control, n=20). RESULTS: Intervention infants remained longer (P<0.001) and had greater whole-body bone mineral content (P=0.02) until 12-month CA compared with controls. Intervention infants born less than or equal to 1250 g continued to have a larger mean head circumference throughout the first year of life (P<0.0001). Human milk feeding ( differed between groups at 6- (P=0.035), but not 12-month CA. No statistically significant differences were found between groups in the mental, motor, or behavior rating scale scores of the Bayley II at 18-month CA. CONCLUSIONS: Adding a multinutrient fortifier to HM provided to predominantly HM-fed premature infants early after discharge results in sustained differences in weight, length, and whole-body bone mineral content, and in smaller babies, head circumference for the first year of life.
Ashley Aimone; Joanne Rovet; Wendy Ward; Ann Jefferies; Douglas M Campbell; Elizabeth Asztalos; Mark Feldman; Jennifer Vaughan; Carol Westall; Hilary Whyte; Deborah L O'Connor;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  49     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-29     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  456-66     Citation Subset:  IM    
Physiology and Experimental Medicine Program and the Department of Clinical Dietetics, Hospital for Sick Children, and Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Body Composition*
Body Size
Bone Density
Dietary Supplements*
Energy Intake
Follow-Up Studies
Head / anatomy & histology
Infant Formula / chemistry
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature / growth & development*
Infant, Small for Gestational Age / growth & development
Intention to Treat Analysis
Milk, Human*
Patient Discharge
Treatment Outcome
Grant Support
//Canadian Institutes of Health Research
Sobia Khan / ; Karen Weishuhn / ; Mary Webster / ; Dineke Klaassen / ; Kirsten Kotsopoulos / ; Kirsten McFadyen / ; Pauline Darling / ; Andrea Nash / ; Debby Arts-Rodas / ; Sandra Gabriele / ; Jaimie MacKinnon / ; Peter Azzopardi / ; Jelena Popovic /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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