| The growing impact of pediatric pharmaceutical poisoning. | |
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MedLine Citation:
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PMID: 21920539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To understand which medications, under which circumstances, are responsible for the noted increase in pediatric medication poisonings, resource use, and morbidity. STUDY DESIGN: Patient records from 2001-2008 were obtained from the National Poison Data System of the American Association of Poison Control Centers for children aged ≤5 years evaluated in a health care facility following exposure to a potentially toxic dose of a pharmaceutical agent. Pharmaceutical agents were classified as over-the-counter or prescription and by functional category. Exposures were classified as child self-ingested the medication or as therapeutic error. For the 8-year period, emergency visits, admissions, significant injuries, and trends in these events were calculated for each substance category. RESULTS: We evaluated 453 559 children for ingestion of a single pharmaceutical product. Child self-exposure was responsible for 95% of visits. Child self-exposure to prescription products dominated the health care impact with 248 023 of the visits (55%), 41 847 admissions (76%), and 18 191 significant injuries (71%). The greatest resource use and morbidity followed self-ingestion of prescription products, particularly opioids, sedative-hypnotics, and cardiovascular agents. CONCLUSIONS: Prevention efforts have proved to be inadequate in the face of rising availability of prescription medications, particularly more dangerous medications. |
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Authors:
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G Randall Bond; Randall W Woodward; Mona Ho |
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Publication Detail:
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Type: Journal Article Date: 2011-09-13 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 160 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-13 Completed Date: 2012-02-28 Revised Date: 2012-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 265-270.e1 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA. randall.bond@cchmc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Analgesics, Opioid / administration & dosage, adverse effects Cardiovascular Agents / administration & dosage, adverse effects Child, Preschool Female Follow-Up Studies Hospitalization / statistics & numerical data* Humans Hypnotics and Sedatives / administration & dosage, adverse effects Infant Infant, Newborn Male Nonprescription Drugs / administration & dosage, adverse effects Pharmaceutical Preparations / administration & dosage Poison Control Centers / organization & administration, statistics & numerical data Prescription Drugs / administration & dosage*, adverse effects* Risk Factors United States |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Cardiovascular Agents; 0/Hypnotics and Sedatives; 0/Nonprescription Drugs; 0/Pharmaceutical Preparations; 0/Prescription Drugs |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2012 Feb;160(2):190-2
[PMID:
22056349
]
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Erratum In:
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J Pediatr. 2012 May;160(5):888-9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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