Document Detail

Group A Streptococcus Meningitis in Children.
MedLine Citation:
PMID:  22926217     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To characterize the epidemiologic burden and the molecular determinants of group A streptococcal (GAS) meningitis among the pediatric population of the state of Paraná, Brazil. PATIENTS AND METHODS: Clinical and epidemiologic data were gathered by a compulsory notification system during the period 2003-2011. Bacterial identification, antibiotic resistance profile, emm-typing, pulsed field gel electrophoresis typing and virulence profile were analyzed by a central reference laboratory. A review of published pediatric cases of GAS meningitis from the last 45 years was undertaken and compared with the Brazilian series. RESULTS: The incidence of GAS meningitis among the pediatric population was 0.06 cases per 100,000 children per year and was associated with a case fatality rate of 43%. Neonatal age and the presence of an associated toxic shock syndrome were identified as risk factors for death. A distant focus of infection was present in more than half of the patients in the literature and in 36% in the Brazilian case series. A high diversity of emm-types was associated with GAS meningitis in Brazil. No single virulence determinant could be associated with death. CONCLUSIONS: Group A streptococcal meningitis is associated with high mortality and with a high diversity of GAS emm-types and virulence determinants in Brazil.
Rosângela Stadnick Lauth de Almeida Torres; Luiz Ernesto Fedalto; Rômulo Francisco de Almeida Torres; Andrew C Steer; Pierre Robert Smeesters
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-24
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Laboratório de Bacteriologia, Divisão de Laboratórios de Epidemiologia e Controle de Doenças, Laboratório Central do Estado do Paraná, Curitiba, Paraná, Brasil. 2Universidade Positivo, Curitiba, Paraná, Brasil. 3Centre for International Child Health, University of Melbourne, Australia 4Infectious diseases and Microbiology group, Murdoch Children's Research Institute, Parkville, Melbourne, Victoria, Australia 5Laboratory of Bacterial Genetics and Physiology, IBMM, Faculté des Sciences, Université Libre de Bruxelles, Belgium.
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